2939748-69-1
2939748-69-1
Chemical Structure
PDE3/4-IN-3
- No. CAS: 2939748-69-1
- Formula:C26H28D3N5O4
- Molecular Weight:480.57
InChIKey: CSOBIBXVIYAXFM-QFJNNGLOSA-N
SMILES: O=C(N1C(C2=CC(OC([2H])([2H])[2H])=C(OC)C=C2CC1)=C/3)N(CCNC(N)=O)C3=N\C4=C(C=C(C)C=C4C)C
Biological Activity: PDE3/4-IN-3 (Compound 7) is an orally active dual PDE3/4 inhibitor with IC50 s of 0.17 and ≤50 nM for PDE3A and PDE4B2, respectively. PDE3/4-IN-3 significantly inhibits methacholine-induced bronchoconstriction in guinea pigs. PDE3/4-IN-3 can be used for chronic obstructive pulmonary disease (COPD) and asthma research[1].
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PDE3/4-IN-3 | PDE3/4-IN-3 (Compound 7) is an orally active dual PDE3/4 inhibitor with IC50 s of 0.17 and ≤50 nM for PDE3A and PDE4B2, respectively. PDE3/4-IN-3 significantly inhibits methacholine-induced bronchoconstriction in guinea pigs. PDE3/4-IN-3 can be used for chronic obstructive pulmonary disease (COPD) and asthma research. | |||||||||||||||||||||
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Ensifentrine-d6 | Ensifentrine-d6 (RPL-554-d6) is deuterium labeled Ensifentrine. Ensifentrine (RPL-554) is an inhaled first-in-class dual inhibitor of phosphodiesterase 3 (PDE3) and PDE4 with IC50s of 0.4 nM and 1479 nM, respectively. Ensifentrine has bronchoprotective and anti-inflammatory activities. Ensifentrine can be used for chronic obstructive pulmonary disease (COPD) research. | |||||||||||||||||||||
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Ensifentrine | 99.36% | Ensifentrine (RPL-554) is an inhaled dual inhibitor of PDE3 and PDE4 with IC50s of 0.4 nM and 1479 nM, respectively. Ensifentrine blocks PDE3 and PDE4 enzymes, thereby increasing the levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) in lung cells, dilating the bronchi, and inhibiting the activation and migration of inflammatory cells. Ensifentrine can be used in the research of chronic obstructive pulmonary disease (COPD). | ||||||||||||||||||||
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References
