Prkar2a - protein kinase cAMP-dependent type II regulatory subunit alpha Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29699

Summary

Enables several functions, including beta-2 Adrenergic Receptor binding activity; cAMP binding activity; and cAMP-dependent protein kinase regulator activity. Involved in regulation of protein kinase activity and response to clozapine. Located in T-tubule and perinuclear region of cytoplasm. Part of cAMP-dependent protein kinase complex. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Prkar2a Products (1)

mRNA Protein Name
NM_019264.2 NP_062137.1 cAMP-dependent protein kinase type II-alpha regulatory subunit

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables beta-2 adrenergic receptor binding IPI
IPI: Inferred from physical interaction
20395454 RGD
enables cAMP binding IDA
IDA: Inferred from direct assay
11907174 RGD
enables cAMP-dependent protein kinase regulator activity IDA
IDA: Inferred from direct assay
11907174 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
17081990 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10618500 RGD
enables protein domain specific binding IDA
IDA: Inferred from direct assay
16306226 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
17081990 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
17081990 RGD
enables small molecule binding IDA
IDA: Inferred from direct assay
21177871 RGD
Biological Process GO Annotation Evidence Referencias Source
involved in regulation of protein kinase activity IDA
IDA: Inferred from direct assay
11907174 RGD
Cellular Component GO Annotation Evidence Referencias Source
located in T-tubule IDA
IDA: Inferred from direct assay
14569017 RGD
part of cAMP-dependent protein kinase complex IDA
IDA: Inferred from direct assay
11907174 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
18550536 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
17081990 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cAMP-dependent protein kinase type II-alpha regulatory subunit

  • protein kinase cAMP-dependent type 2 regulatory subunit alpha

  • protein kinase, cAMP dependent regulatory, type II alpha

  • protein kinase, cAMP-dependent, regulatory subunit type II alpha

  • protein kinase, cAMP-dependent, regulatory, type 2, alpha

Prkar2a Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Cross
Prkar2a P12368 PDE4DIP Homo sapiens Q5VU43-11
Anti Bait CoIP
21569246
Cross
Prkar2a P12368 PDE4DIP Homo sapiens Q5VU43-11
Anti Tag CoIP
21569246
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS11114 PRKAR2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22020 Prkar2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28538 Prkar2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prkar2a NCBI NCBI:5576