Gabrg2 - gamma-aminobutyric acid type A receptor subunit gamma 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29709

Summary

Enables GABA-A receptor activity and Chloride Channel activity. Contributes to GABA Receptor activity. Involved in GABAergic synaptic transmission. Located in cytoplasm; dendrite membrane; and inhibitory synapse. Part of GABA Receptor complex. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic specialization membrane. Biomarker of hepatic encephalopathy. Human ortholog(s) of this gene implicated in childhood absence epilepsy; developmental and epileptic encephalopathy 74; and familial febrile seizures 8. Orthologous to human GABRG2 (gamma-aminobutyric acid type A receptor subunit gamma2). [provided by Alliance of Genome Resources, Apr 2022]

Gabrg2 Products (2)

mRNA Protein Name
NM_001393775.1 NP_001380704.1 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor
NM_183327.2 NP_899156.1 gamma-aminobutyric acid receptor subunit gamma-2 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
contributes to GABA receptor activity IDA
IDA: Inferred from direct assay
12930820 RGD
enables GABA-A receptor activity IDA
IDA: Inferred from direct assay
2561970 RGD
enables chloride channel activity IDA
IDA: Inferred from direct assay
2561970 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12091434 RGD
Biological Process GO Annotation Evidence Referencias Source
involved in cellular response to zinc ion IDA
IDA: Inferred from direct assay
20371809 RGD
involved in chloride transport IDA
IDA: Inferred from direct assay
2561970 RGD
involved in response to anesthetic IMP
IMP: Inferred from mutant phenotype
16037152 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
11410716 RGD
involved in synaptic transmission, GABAergic IDA
IDA: Inferred from direct assay
12930820 RGD
Cellular Component GO Annotation Evidence Referencias Source
part of GABA receptor complex IDA
IDA: Inferred from direct assay
12930820 RGD
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
9014159 RGD
located in cell surface IDA
IDA: Inferred from direct assay
17989301 RGD
located in dendrite membrane IDA
IDA: Inferred from direct assay
15620359 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
9464994 RGD
located in inhibitory synapse IDA
IDA: Inferred from direct assay
20417281 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
9464994 RGD
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
9014159 RGD
located in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
9464994 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gamma-aminobutyric acid receptor subunit gamma-2

  • GABA(A) receptor subunit gamma-2

  • gamma-aminobutyric acid (GABA) A receptor, gamma 2

  • gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2

  • gamma-aminobutyric acid A receptor, gamma 2

  • gamma-aminobutyric acid type A receptor gamma 2 subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS05221 GABRG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gabrg2 NCBI NCBI:2566