FSD1 - fibronectin type III and SPRY domain containing 1 Gene

Also Known as MIR1; GLFND

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79187

About FSD1

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,304,598-4,323,836 (from NCBI)

This gene has 10 transcripts (splice variants), 197 orthologues and 3 paralogues. Biased expression in brain (RPKM 10.1), testis (RPKM 4.8) and 2 other tissues.

Summary

This gene encodes a centrosome associated protein that is characterized by an N-terminal coiled-coil region downstream of B-box (BBC) domain, a central fibronectin type III domain, and a C-terminal repeats in splA and RyR (SPRY) domain. The encoded protein associates with a subset of microtubules and may be involved in the stability and organization of microtubules during cytokinesis. [provided by RefSeq, Apr 2009]

FSD1 Products (2)

mRNA Protein Name
NM_001330429.2 NP_001317358.1 fibronectin type III and SPRY domain-containing protein 1 isoform 2
NM_024333.3 NP_077309.1 fibronectin type III and SPRY domain-containing protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
12154070 GOA
enables microtubule binding IMP
IMP: Inferred from mutant phenotype
12154070 GOA
Biological Process GO Annotation Evidence Referencias Source
involved in cytoplasmic microtubule organization IMP
IMP: Inferred from mutant phenotype
12154070 GOA
involved in regulation of cell division IDA
IDA: Inferred from direct assay
12445389 GOA
involved in regulation of cytokinesis IDA
IDA: Inferred from direct assay
12445389 GOA
involved in regulation of mitotic spindle organization IDA
IDA: Inferred from direct assay
12154070 GOA
Cellular Component GO Annotation Evidence Referencias Source
located in centrosome IMP
IMP: Inferred from mutant phenotype
12154070 GOA
located in microtubule IMP
IMP: Inferred from mutant phenotype
12154070 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fibronectin type III and SPRY domain-containing protein 1

  • MID1-related protein 1

Related Diseases

Diseases Alias
Mitochondrial Dna Depletion Syndrome 12a
Spastic Paraplegia 16, X-Linked

  • SPG16

  • Hereditary Spastic Paraplegia 16

  • X-Linked Spastic Paraplegia Type 16

  • Spastic Paraplegia 16, X-Linked, Complicated

  • X-Linked Spastic Paraplegia 16

  • Spastic Paraplegia 16

  • Spastic Paraplegia-16, X-Linked, Complicated
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS05121 FSD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus FSD1 VGNC VGNC:62375
Rattus norvegicus FSD1 RGD RGD:1583850
Canis familiaris FSD1 VGNC VGNC:40993
Bos taurus FSD1 VGNC VGNC:29129
Mus musculus FSD1 MGD MGI:1934858
Macaca mulatta FSD1 VGNC VGNC:72718