ARPC1B - actin related protein 2/3 complex subunit 1B Gene

Also Known as ARC41; IMD71; PLTEID; p40-ARC; p41-ARC

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10095

About ARPC1B

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:99,374,259-99,394,816 (from NCBI)

This gene has 25 transcripts (splice variants), 212 orthologues, 1 paralogue and is associated with 1 phenotype. Broad expression in spleen (RPKM 111.2), appendix (RPKM 92.6) and 24 other tissues.

Summary

This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011]

ARPC1B Products (1)

mRNA	Protein	Name
NM_005720.4	NP_005711.1	actin-related protein 2月3日 complex subunit 1B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to actin filament binding	IDA IDA: Inferred from direct assay	11741539	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25944859	GOA
enables structural constituent of cytoskeleton	IDA IDA: Inferred from direct assay	11741539	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Arp2/3 complex-mediated actin nucleation	IDA IDA: Inferred from direct assay	11741539	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Arp2/3 protein complex	IDA IDA: Inferred from direct assay	11741539	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARPC1B Protein Structure

WD40

0
100
200
300
372 a.a.

Protein Preferred Names	Protein Names
actin-related protein 2/3 complex subunit 1B	ARP2/3 protein complex subunit p41

Related Diseases

Diseases	Alias
Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia	Platelet Abnormalities With Eosinophilia And Immune-Mediated Inflammatory Disease IMD71 Plteid Immunodeficiency 71
Combined T And B Cell Immunodeficiency
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Immunodeficiency 63 With Lymphoproliferation And Autoimmunity	IMD63 Il2rb Deficiency Cd122 Deficiency Immunodeficiency 63 Interleukin 2 Receptor, Beta, Deficiency Of Deficiency Of Interleukin 2 Receptor Beta
Wiskott-Aldrich Syndrome	WAS Eczema-Thrombocytopenia-Immunodeficiency Syndrome Immunodeficiency 2 Aldrich Syndrome Imd2 Wiskott-Aldrich Syndrome 1 Was1 Wiskott Syndrome Wiskott Aldrich Syndrome Eczema Thrombocytopenia Immunodeficiency Syndrome Imd 2
Cd3zeta Deficiency
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01014	ARPC1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ARPC1B	VGNC	VGNC:68245
Bos taurus	ARPC1B	VGNC	VGNC:26164
Mus musculus	ARPC1B	MGD	MGI:1343142
Rattus norvegicus	ARPC1B	RGD	RGD:2155
Canis familiaris	ARPC1B	VGNC	VGNC:38131