2. Gene
  3. Pms2 - PMS1 homolog2, mismatch repair system component Gene

Pms2 - PMS1 homolog2, mismatch repair system component Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Pmsl2

Gene ID: 18861 | Gene type: protein coding

About Pms2

Summary

Predicted to enable ATP hydrolysis activity and single base insertion or deletion binding activity. Predicted to contribute to MutSalpha complex binding activity and single-stranded DNA binding activity. Involved in positive regulation of isotype switching to IgA isotypes; positive regulation of isotype switching to IgG isotypes; and somatic hypermutation of immunoglobulin genes. Acts upstream of or within mismatch repair and somatic recombination of immunoglobulin gene segments. Part of MutLalpha complex. Is expressed in cerebellum; lower urogenital tract; reproductive system; retina; and urethra epithelium. Human ortholog(s) of this gene implicated in Lynch syndrome; hereditary nonpolyposis colorectal Cancer type 4; mismatch repair Cancer syndrome; ovarian cancer; and urinary bladder Cancer. Orthologous to human PMS2 (PMS1 homolog 2, mismatch repair system component). [provided by Alliance of Genome Resources, Apr 2022]

Pms2 Products(1)

mRNA Protein Name
NM_008886.3 NP_032912.2 mismatch repair endonuclease PMS2
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within DNA damage response IGI
IGI: Inferred from genetic interaction
16204034 MGI
acts upstream of or within DNA damage response IMP
IMP: Inferred from mutant phenotype
16204034 MGI
acts upstream of or within DNA repair IMP
IMP: Inferred from mutant phenotype
15480418 MGI
acts upstream of or within mismatch repair IGI
IGI: Inferred from genetic interaction
16204034 MGI
acts upstream of or within mismatch repair IMP
IMP: Inferred from mutant phenotype
9500552 MGI
involved in positive regulation of isotype switching to IgA isotypes IGI
IGI: Inferred from genetic interaction
10430621 MGI
involved in positive regulation of isotype switching to IgA isotypes IMP
IMP: Inferred from mutant phenotype
10430621 MGI
involved in positive regulation of isotype switching to IgG isotypes IGI
IGI: Inferred from genetic interaction
10430621 MGI
involved in positive regulation of isotype switching to IgG isotypes IMP
IMP: Inferred from mutant phenotype
10430621 MGI
acts upstream of or within somatic hypermutation of immunoglobulin genes IMP
IMP: Inferred from mutant phenotype
10429667 MGI
involved in somatic hypermutation of immunoglobulin genes IMP
IMP: Inferred from mutant phenotype
9618520 MGI
acts upstream of or within somatic recombination of immunoglobulin gene segments IMP
IMP: Inferred from mutant phenotype
11828012 MGI
Cellular Component GO Annotation Evidence Reference Source
part of MutLalpha complex IDA
IDA: Inferred from direct assay
16713580 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mismatch repair endonuclease PMS2

DNA mismatch repair protein PMS2

PMS1 protein homolog 2

postmeiotic segregation increased 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-173455 NP1867 Inhibitor / Unkown
HY-RS10773 PMS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pms2 NCBI NCBI:5395