Pms2 - PMS1 homolog2, mismatch repair system component Gene

Also Known as Pmsl2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18861

Summary

Predicted to enable ATP hydrolysis activity and single base insertion or deletion binding activity. Predicted to contribute to MutSalpha complex binding activity and single-stranded DNA binding activity. Involved in positive regulation of isotype switching to IgA isotypes; positive regulation of isotype switching to IgG isotypes; and somatic hypermutation of immunoglobulin genes. Acts upstream of or within mismatch repair and somatic recombination of immunoglobulin gene segments. Part of MutLalpha complex. Is expressed in cerebellum; lower urogenital tract; reproductive system; retina; and urethra epithelium. Human ortholog(s) of this gene implicated in Lynch syndrome; hereditary nonpolyposis colorectal Cancer type 4; mismatch repair Cancer syndrome; ovarian cancer; and urinary bladder Cancer. Orthologous to human PMS2 (PMS1 homolog 2, mismatch repair system component). [provided by Alliance of Genome Resources, Apr 2022]

Pms2 Products (1)

mRNA	Protein	Name
NM_008886.3	NP_032912.2	mismatch repair endonuclease PMS2

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within DNA damage response	IGI IGI: Inferred from genetic interaction	16204034	MGI
acts upstream of or within DNA damage response	IMP IMP: Inferred from mutant phenotype	16204034	MGI
acts upstream of or within DNA repair	IMP IMP: Inferred from mutant phenotype	15480418	MGI
acts upstream of or within mismatch repair	IGI IGI: Inferred from genetic interaction	16204034	MGI
acts upstream of or within mismatch repair	IMP IMP: Inferred from mutant phenotype	9500552	MGI
involved in positive regulation of isotype switching to IgA isotypes	IGI IGI: Inferred from genetic interaction	10430621	MGI
involved in positive regulation of isotype switching to IgA isotypes	IMP IMP: Inferred from mutant phenotype	10430621	MGI
involved in positive regulation of isotype switching to IgG isotypes	IGI IGI: Inferred from genetic interaction	10430621	MGI
involved in positive regulation of isotype switching to IgG isotypes	IMP IMP: Inferred from mutant phenotype	10430621	MGI
acts upstream of or within somatic hypermutation of immunoglobulin genes	IMP IMP: Inferred from mutant phenotype	10429667	MGI
involved in somatic hypermutation of immunoglobulin genes	IMP IMP: Inferred from mutant phenotype	9618520	MGI
acts upstream of or within somatic recombination of immunoglobulin gene segments	IMP IMP: Inferred from mutant phenotype	11828012	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of MutLalpha complex	IDA IDA: Inferred from direct assay	16713580	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
mismatch repair endonuclease PMS2	DNA mismatch repair protein PMS2 PMS1 protein homolog 2 postmeiotic segregation increased 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-173455	NP1867	Inhibitor	/	Unkown
HY-RS10773	PMS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pms2	NCBI	NCBI:5395