Prph2 - peripherin 2 Gene

Also Known as RP7; Rd2; Rds; rds; AVMD; PRPH; Rd-2; AOFMD; Nmf193; Tspan22

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19133

Summary

Enables protein homodimerization activity. Acts upstream of or within several processes, including detection of light stimulus involved in visual perception; photoreceptor cell outer segment organization; and protein complex oligomerization. Located in photoreceptor outer segment. Is expressed in eye; head; retina; and retina outer nuclear layer. Used to study patterned macular dystrophy 1 and retinitis pigmentosa 7. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; eye degenerative disease (multiple); and fundus albipunctatus. Orthologous to human PRPH2 (peripherin 2). [provided by Alliance of Genome Resources, Apr 2022]

Prph2 Products (1)

mRNA Protein Name
NM_008938.2 NP_032964.1 peripherin-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20055437 MGI
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
20055437 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within detection of light stimulus involved in visual perception IGI
IGI: Inferred from genetic interaction
28053051 MGI
acts upstream of or within detection of light stimulus involved in visual perception IMP
IMP: Inferred from mutant phenotype
26420485 MGI
acts upstream of or within photoreceptor cell outer segment organization IGI
IGI: Inferred from genetic interaction
28053051 MGI
acts upstream of or within photoreceptor cell outer segment organization IMP
IMP: Inferred from mutant phenotype
28053051 MGI
acts upstream of or within protein heterooligomerization IPI
IPI: Inferred from physical interaction
20055437 MGI
acts upstream of or within protein homooligomerization IPI
IPI: Inferred from physical interaction
20055437 MGI
acts upstream of or within retina development in camera-type eye IGI
IGI: Inferred from genetic interaction
28053051 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
15964665 MGI
Cellular Component GO Annotation Evidence References Source
located in photoreceptor outer segment IDA
IDA: Inferred from direct assay
22183407 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

peripherin-2

  • retinal degeneration 2

  • retinal degeneration slow protein

  • retinal degeneration, slow (retinitis pigmentosa 7)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11218 PRPH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prph2 NCBI NCBI:5961