Wdr19 - WD repeat domain 19 Gene

Also Known as DYF2; PWDMP; Ift144; mKIAA1638; C330027H04Rik; D330023L08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 213081

Summary

Acts upstream of or within several processes, including embryonic organ development; myotome development; and smoothened signaling pathway. Located in motile cilium and photoreceptor connecting cilium. Part of intraciliary transport particle A. Is expressed in prostate gland; salivary gland; and testis. Used to study ciliopathy. Human ortholog(s) of this gene implicated in several diseases, including Caroli disease; Senior-Loken syndrome; asphyxiating thoracic dystrophy 5; cranioectodermal dysplasia 4; and nephronophthisis 13. Orthologous to human WDR19 (WD repeat domain 19). [provided by Alliance of Genome Resources, Apr 2022]

Wdr19 Products (3)

mRNA Protein Name
NM_001359879.1 NP_001346808.1 WD repeat-containing protein 19 isoform a
NM_001359880.1 NP_001346809.1 WD repeat-containing protein 19 isoform a
NM_153391.2 NP_700440.2 WD repeat-containing protein 19 isoform a

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell morphogenesis IMP
IMP: Inferred from mutant phenotype
22228095 MGI
acts upstream of or within cilium assembly IGI
IGI: Inferred from genetic interaction
22689656 MGI
acts upstream of or within cilium assembly IMP
IMP: Inferred from mutant phenotype
22228095 MGI
acts upstream of or within digestive system development IMP
IMP: Inferred from mutant phenotype
22228095 MGI
acts upstream of or within ear morphogenesis IMP
IMP: Inferred from mutant phenotype
22228095 MGI
acts upstream of or within embryonic camera-type eye development IMP
IMP: Inferred from mutant phenotype
22228095 MGI
acts upstream of or within embryonic cranial skeleton morphogenesis IMP
IMP: Inferred from mutant phenotype
22228095 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: Inferred from mutant phenotype
22228095 MGI
acts upstream of or within gonad development IMP
IMP: Inferred from mutant phenotype
25224227 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
22228095 MGI
acts upstream of or within myotome development IMP
IMP: Inferred from mutant phenotype
22228095 MGI
acts upstream of or within nervous system process IMP
IMP: Inferred from mutant phenotype
22228095 MGI
acts upstream of or within receptor clustering IGI
IGI: Inferred from genetic interaction
22689656 MGI
acts upstream of or within smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
22228095 MGI
acts upstream of or within smoothened signaling pathway involved in dorsal/ventral neural tube patterning IGI
IGI: Inferred from genetic interaction
22689656 MGI
acts upstream of or within smoothened signaling pathway involved in dorsal/ventral neural tube patterning IMP
IMP: Inferred from mutant phenotype
22689656 MGI
Cellular Component GO Annotation Evidence References Source
located in cilium IDA
IDA: Inferred from direct assay
22228095 MGI
part of intraciliary transport particle A IDA
IDA: Inferred from direct assay
20889716 MGI
located in motile cilium IDA
IDA: Inferred from direct assay
16957054 MGI
located in non-motile cilium IDA
IDA: Inferred from direct assay
16957054 MGI
located in photoreceptor connecting cilium IDA
IDA: Inferred from direct assay
19208653 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

WD repeat-containing protein 19

  • WD repeat membrane protein PWDMP

  • intraflagellar transport 144 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15766 WDR19 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wdr19 NCBI NCBI:57728