Ift88 - intraflagellar transport 88 Gene

Mus musculus

Also known as fxo; orpk; Tg737; Ttc10; flexo; polaris; Tg737Rpw; TgN737Rpw

Gene ID: 21821 | Gene type: protein coding

About Ift88

Summary

Enables Kinesin binding activity. Involved in regulation of autophagosome assembly and regulation of cilium assembly. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and spermatid development. Located in several cellular components, including axonemal basal plate; microtubule organizing center; and non-motile cilium. Part of intraciliary transport particle B. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and respiratory system. Used to study autosomal recessive polycystic kidney disease and mitral valve disease. Orthologous to human IFT88 (intraflagellar transport 88). [provided by Alliance of Genome Resources, Apr 2022]

Ift88 Products(6)

mRNA	Protein	Name
NM_001404393.1	NP_001391322.1	intraflagellar transport protein 88 homolog isoform 2
NM_001404394.1	NP_001391323.1	intraflagellar transport protein 88 homolog isoform 3
NM_001404395.1	NP_001391324.1	intraflagellar transport protein 88 homolog isoform 4
NM_001404396.1	NP_001391325.1	intraflagellar transport protein 88 homolog isoform 5
NM_001404397.1	NP_001391326.1	intraflagellar transport protein 88 homolog isoform 6
NM_009376.3	NP_033402.2	intraflagellar transport protein 88 homolog isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables kinesin binding	IPI IPI: Inferred from physical interaction	19384852	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11062270	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	21703454	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	15226261	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	12701101	MGI
acts upstream of or within brain development	IGI IGI: Inferred from genetic interaction	22228099	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	19036983	MGI
acts upstream of or within cardiac muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	19654211	MGI
acts upstream of or within cardiac septum morphogenesis	IMP IMP: Inferred from mutant phenotype	19036983	MGI
acts upstream of or within cilium assembly	IMP IMP: Inferred from mutant phenotype	19654211	MGI
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	11062270	MGI
acts upstream of or within cilium movement	IMP IMP: Inferred from mutant phenotype	29891944	MGI
acts upstream of or within cochlea development	IGI IGI: Inferred from genetic interaction	18066062	MGI
acts upstream of or within cytoplasmic microtubule organization	IMP IMP: Inferred from mutant phenotype	21703454	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	10804177	MGI
acts upstream of or within dorsal/ventral pattern formation	IMP IMP: Inferred from mutant phenotype	15755804	MGI
acts upstream of or within embryonic digit morphogenesis	IGI IGI: Inferred from genetic interaction	15930098	MGI
acts upstream of or within embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	12701101	MGI
acts upstream of or within endothelial cell morphogenesis	IMP IMP: Inferred from mutant phenotype	21285373	MGI
acts upstream of or within epidermal stem cell homeostasis	IMP IMP: Inferred from mutant phenotype	21429982	MGI
acts upstream of or within epidermis development	IMP IMP: Inferred from mutant phenotype	21703454	MGI
acts upstream of or within eye development	IGI IGI: Inferred from genetic interaction	22228099	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	28291836	MGI
acts upstream of or within forebrain morphogenesis	IMP IMP: Inferred from mutant phenotype	19036983	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	22228099	MGI
acts upstream of or within heart formation	IMP IMP: Inferred from mutant phenotype	19654211	MGI
acts upstream of or within inner ear receptor cell stereocilium organization	IGI IGI: Inferred from genetic interaction	18066062	MGI
acts upstream of or within inner ear receptor cell stereocilium organization	IMP IMP: Inferred from mutant phenotype	18066062	MGI
acts upstream of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	21703454	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	9176412	MGI
acts upstream of or within limb development	IGI IGI: Inferred from genetic interaction	22228099	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	9176412	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	19036983	MGI
acts upstream of or within lung vasculature development	IMP IMP: Inferred from mutant phenotype	19036983	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	21703454	MGI
acts upstream of or within negative regulation of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	21703454	MGI
acts upstream of or within nervous system development	IMP IMP: Inferred from mutant phenotype	19036983	MGI
acts upstream of or within neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	18297065	MGI
acts upstream of or within non-motile cilium assembly	IMP IMP: Inferred from mutant phenotype	16254602	MGI
acts upstream of or within pancreas development	IMP IMP: Inferred from mutant phenotype	11773599	MGI
acts upstream of or within positive regulation of insulin-like growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19596798	MGI
acts upstream of or within primary palate development	IGI IGI: Inferred from genetic interaction	22228099	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	22228099	MGI
involved in regulation of autophagosome assembly	IMP IMP: Inferred from mutant phenotype	24089209	MGI
involved in regulation of cilium assembly	IMP IMP: Inferred from mutant phenotype	24089209	MGI
acts upstream of or within regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	19596798	MGI
acts upstream of or within regulation of feeding behavior	IMP IMP: Inferred from mutant phenotype	23599282	MGI
acts upstream of or within regulation of odontogenesis of dentin-containing tooth	IMP IMP: Inferred from mutant phenotype	12701101	MGI
acts upstream of or within regulation of protein processing	IMP IMP: Inferred from mutant phenotype	15930098	MGI
acts upstream of or within response to fluid shear stress	IMP IMP: Inferred from mutant phenotype	18285569	MGI
acts upstream of or within smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	15930098	MGI
acts upstream of or within smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	15930098	MGI
acts upstream of or within sperm axoneme assembly	IMP IMP: Inferred from mutant phenotype	21337470	MGI
acts upstream of or within spermatid nucleus elongation	IMP IMP: Inferred from mutant phenotype	21337470	MGI
acts upstream of or within spinal cord dorsal/ventral patterning	IMP IMP: Inferred from mutant phenotype	21761479	MGI
acts upstream of or within telencephalon development	IMP IMP: Inferred from mutant phenotype	19036983	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in acrosomal membrane	IDA IDA: Inferred from direct assay	21337470	MGI
located in axonemal basal plate	IDA IDA: Inferred from direct assay	24302887	MGI
located in axoneme	IDA IDA: Inferred from direct assay	11251073	MGI
located in centriole	IDA IDA: Inferred from direct assay	20230748	MGI
located in centrosome	IDA IDA: Inferred from direct assay	19253336	MGI
located in ciliary basal body	IDA IDA: Inferred from direct assay	11251073	MGI
located in ciliary base	IDA IDA: Inferred from direct assay	16775004	MGI
located in ciliary tip	IDA IDA: Inferred from direct assay	16775004	MGI
located in cilium	IDA IDA: Inferred from direct assay	18285569	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	27682589	MGI
part of intraciliary transport particle B	IDA IDA: Inferred from direct assay	12821668	MGI
located in kinocilium	IDA IDA: Inferred from direct assay	18066062	MGI
located in manchette	IDA IDA: Inferred from direct assay	34124066	MGI
located in motile cilium	IDA IDA: Inferred from direct assay	18590716	MGI
located in non-motile cilium	IDA IDA: Inferred from direct assay	16254602	MGI
located in photoreceptor connecting cilium	IDA IDA: Inferred from direct assay	19208653	MGI
located in sperm flagellum	IDA IDA: Inferred from direct assay	27682589	MGI
located in sperm head-tail coupling apparatus	IDA IDA: Inferred from direct assay	34124066	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

intraflagellar transport protein 88 homolog

TPR repeat protein 10	intraflagellar transport 88 homolog
recessive polycystic kidney disease protein Tg737	tetratricopeptide repeat domain 10
tetratricopeptide repeat protein 10	tgN(Imorpk)737Rpw
transgene insert site 737, insertional mutation, pol

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06610	IFT88 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ift88	NCBI	NCBI:8100

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