Ift88 - intraflagellar transport 88 Gene

Also Known as fxo; orpk; Tg737; Ttc10; flexo; polaris; Tg737Rpw; TgN737Rpw

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21821

Summary

Enables Kinesin binding activity. Involved in regulation of autophagosome assembly and regulation of cilium assembly. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and spermatid development. Located in several cellular components, including axonemal basal plate; microtubule organizing center; and non-motile cilium. Part of intraciliary transport particle B. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and respiratory system. Used to study autosomal recessive polycystic kidney disease and mitral valve disease. Orthologous to human IFT88 (intraflagellar transport 88). [provided by Alliance of Genome Resources, Apr 2022]

Ift88 Products (6)

mRNA Protein Name
NM_001404393.1 NP_001391322.1 intraflagellar transport protein 88 homolog isoform 2
NM_001404394.1 NP_001391323.1 intraflagellar transport protein 88 homolog isoform 3
NM_001404395.1 NP_001391324.1 intraflagellar transport protein 88 homolog isoform 4
NM_001404396.1 NP_001391325.1 intraflagellar transport protein 88 homolog isoform 5
NM_001404397.1 NP_001391326.1 intraflagellar transport protein 88 homolog isoform 6
NM_009376.3 NP_033402.2 intraflagellar transport protein 88 homolog isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables kinesin binding IPI
IPI: Inferred from physical interaction
19384852 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11062270 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
21703454 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
15226261 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
12701101 MGI
acts upstream of or within brain development IGI
IGI: Inferred from genetic interaction
22228099 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
19036983 MGI
acts upstream of or within cardiac muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
19654211 MGI
acts upstream of or within cardiac septum morphogenesis IMP
IMP: Inferred from mutant phenotype
19036983 MGI
acts upstream of or within cilium assembly IMP
IMP: Inferred from mutant phenotype
19654211 MGI
involved in cilium assembly IMP
IMP: Inferred from mutant phenotype
11062270 MGI
acts upstream of or within cilium movement IMP
IMP: Inferred from mutant phenotype
29891944 MGI
acts upstream of or within cochlea development IGI
IGI: Inferred from genetic interaction
18066062 MGI
acts upstream of or within cytoplasmic microtubule organization IMP
IMP: Inferred from mutant phenotype
21703454 MGI
acts upstream of or within determination of left/right symmetry IMP
IMP: Inferred from mutant phenotype
10804177 MGI
acts upstream of or within dorsal/ventral pattern formation IMP
IMP: Inferred from mutant phenotype
15755804 MGI
acts upstream of or within embryonic digit morphogenesis IGI
IGI: Inferred from genetic interaction
15930098 MGI
acts upstream of or within embryonic digit morphogenesis IMP
IMP: Inferred from mutant phenotype
12701101 MGI
acts upstream of or within endothelial cell morphogenesis IMP
IMP: Inferred from mutant phenotype
21285373 MGI
acts upstream of or within epidermal stem cell homeostasis IMP
IMP: Inferred from mutant phenotype
21429982 MGI
acts upstream of or within epidermis development IMP
IMP: Inferred from mutant phenotype
21703454 MGI
acts upstream of or within eye development IGI
IGI: Inferred from genetic interaction
22228099 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
28291836 MGI
acts upstream of or within forebrain morphogenesis IMP
IMP: Inferred from mutant phenotype
19036983 MGI
acts upstream of or within heart development IGI
IGI: Inferred from genetic interaction
22228099 MGI
acts upstream of or within heart formation IMP
IMP: Inferred from mutant phenotype
19654211 MGI
acts upstream of or within inner ear receptor cell stereocilium organization IGI
IGI: Inferred from genetic interaction
18066062 MGI
acts upstream of or within inner ear receptor cell stereocilium organization IMP
IMP: Inferred from mutant phenotype
18066062 MGI
acts upstream of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
21703454 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
9176412 MGI
acts upstream of or within limb development IGI
IGI: Inferred from genetic interaction
22228099 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
9176412 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
19036983 MGI
acts upstream of or within lung vasculature development IMP
IMP: Inferred from mutant phenotype
19036983 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
21703454 MGI
acts upstream of or within negative regulation of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
21703454 MGI
acts upstream of or within nervous system development IMP
IMP: Inferred from mutant phenotype
19036983 MGI
acts upstream of or within neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
18297065 MGI
acts upstream of or within non-motile cilium assembly IMP
IMP: Inferred from mutant phenotype
16254602 MGI
acts upstream of or within pancreas development IMP
IMP: Inferred from mutant phenotype
11773599 MGI
acts upstream of or within positive regulation of insulin-like growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19596798 MGI
acts upstream of or within primary palate development IGI
IGI: Inferred from genetic interaction
22228099 MGI
acts upstream of or within protein localization IMP
IMP: Inferred from mutant phenotype
22228099 MGI
involved in regulation of autophagosome assembly IMP
IMP: Inferred from mutant phenotype
24089209 MGI
involved in regulation of cilium assembly IMP
IMP: Inferred from mutant phenotype
24089209 MGI
acts upstream of or within regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
19596798 MGI
acts upstream of or within regulation of feeding behavior IMP
IMP: Inferred from mutant phenotype
23599282 MGI
acts upstream of or within regulation of odontogenesis of dentin-containing tooth IMP
IMP: Inferred from mutant phenotype
12701101 MGI
acts upstream of or within regulation of protein processing IMP
IMP: Inferred from mutant phenotype
15930098 MGI
acts upstream of or within response to fluid shear stress IMP
IMP: Inferred from mutant phenotype
18285569 MGI
acts upstream of or within smoothened signaling pathway IGI
IGI: Inferred from genetic interaction
15930098 MGI
acts upstream of or within smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
15930098 MGI
acts upstream of or within sperm axoneme assembly IMP
IMP: Inferred from mutant phenotype
21337470 MGI
acts upstream of or within spermatid nucleus elongation IMP
IMP: Inferred from mutant phenotype
21337470 MGI
acts upstream of or within spinal cord dorsal/ventral patterning IMP
IMP: Inferred from mutant phenotype
21761479 MGI
acts upstream of or within telencephalon development IMP
IMP: Inferred from mutant phenotype
19036983 MGI
Cellular Component GO Annotation Evidence References Source
located in acrosomal membrane IDA
IDA: Inferred from direct assay
21337470 MGI
located in axonemal basal plate IDA
IDA: Inferred from direct assay
24302887 MGI
located in axoneme IDA
IDA: Inferred from direct assay
11251073 MGI
located in centriole IDA
IDA: Inferred from direct assay
20230748 MGI
located in centrosome IDA
IDA: Inferred from direct assay
19253336 MGI
located in ciliary basal body IDA
IDA: Inferred from direct assay
11251073 MGI
located in ciliary base IDA
IDA: Inferred from direct assay
16775004 MGI
located in ciliary tip IDA
IDA: Inferred from direct assay
16775004 MGI
located in cilium IDA
IDA: Inferred from direct assay
18285569 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
27682589 MGI
part of intraciliary transport particle B IDA
IDA: Inferred from direct assay
12821668 MGI
located in kinocilium IDA
IDA: Inferred from direct assay
18066062 MGI
located in manchette IDA
IDA: Inferred from direct assay
34124066 MGI
located in motile cilium IDA
IDA: Inferred from direct assay
18590716 MGI
located in non-motile cilium IDA
IDA: Inferred from direct assay
16254602 MGI
located in photoreceptor connecting cilium IDA
IDA: Inferred from direct assay
19208653 MGI
located in sperm flagellum IDA
IDA: Inferred from direct assay
27682589 MGI
located in sperm head-tail coupling apparatus IDA
IDA: Inferred from direct assay
34124066 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

intraflagellar transport protein 88 homolog

  • TPR repeat protein 10

  • intraflagellar transport 88 homolog

  • recessive polycystic kidney disease protein Tg737

  • tetratricopeptide repeat domain 10

  • tetratricopeptide repeat protein 10

  • tgN(Imorpk)737Rpw

  • transgene insert site 737, insertional mutation, pol

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06610 IFT88 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ift88 NCBI NCBI:8100