HNRNPA3 - heterogeneous nuclear ribonucleoprotein A3 Gene

Also Known as FBRNP; HNRPA3; D10S102; 2610510D13Rik

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 220988

About HNRNPA3

Cytogenetic location: 2q31.2 Genomic coordinates (GRCh38): 2:177,212,794-177,223,959 (from NCBI)

This gene has 19 transcripts (splice variants), 129 orthologues and 36 paralogues. Ubiquitous expression in appendix (RPKM 56.8), lymph node (RPKM 56.0) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Apr 2022]

HNRNPA3 Products (7)

mRNA Protein Name
NM_001330247.2 NP_001317176.1 heterogeneous nuclear ribonucleoprotein A3 isoform b
NM_001330248.2 NP_001317177.1 heterogeneous nuclear ribonucleoprotein A3 isoform b
NM_001330249.2 NP_001317178.1 heterogeneous nuclear ribonucleoprotein A3 isoform a
NM_001330250.2 NP_001317179.1 heterogeneous nuclear ribonucleoprotein A3 isoform c
NM_001330251.2 NP_001317180.1 heterogeneous nuclear ribonucleoprotein A3 isoform c
NM_001395170.1 NP_001382099.1 heterogeneous nuclear ribonucleoprotein A3 isoform d
NM_194247.4 NP_919223.1 heterogeneous nuclear ribonucleoprotein A3 isoform a

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22720776 GOA
Cellular Component GO Annotation Evidence References Source
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in nucleus IDA
IDA: Inferred from direct assay
22720776 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HNRNPA3 Protein Structure

(37 - 106)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (128 - 196)

  • 0
  • 100
  • 200
  • 300
  • 378 a.a.
Protein Preferred Names Protein Names

heterogeneous nuclear ribonucleoprotein A3

  • epididymis secretory sperm binding protein

Related Diseases

Diseases Alias
Multisystem Proteinopathy
X-Linked Hereditary Ataxia
Fragile X-Associated Tremor/Ataxia Syndrome

  • Fxtas Syndrome

  • Fragile X Tremor/Ataxia Syndrome

  • Fxtas
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

  • FTDALS1

  • Frontotemporal Dementia And/Or Motor Neuron Disease

  • Ftdmnd

  • Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia

  • Alsftd

  • Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis

  • Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1

  • Frontotemporal Dementia With Motor Neuron Disease

  • Ftdals

  • Ftd-Als

  • Ftd-Mnd

  • Frontotemporal Dementia With Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1

  • Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

  • Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1

  • Frontotemporal Lobar Degeneration

  • Grn-Related Frontotemporal Dementia
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06263 HNRNPA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HNRNPA3 VGNC VGNC:99367
Mus musculus HNRNPA3 MGD MGI:1917171
Canis familiaris HNRNPA3 VGNC VGNC:41728
Felis catus HNRNPA3 VGNC VGNC:80231
Rattus norvegicus HNRNPA3 RGD RGD:727807
Bos taurus HNRNPA3 VGNC VGNC:50100