country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

DAAM2 - dishevelled associated activator of morphogenesis 2 Gene

Also Known as NPHS24; dJ90A20A.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23500

About DAAM2

Cytogenetic location: 6p21.2 Genomic coordinates (GRCh38): 6:39,792,376-39,904,869 (from NCBI)

This gene has 11 transcripts (splice variants), 200 orthologues, 18 paralogues and is associated with 2 phenotypes. Broad expression in brain (RPKM 23.5), esophagus (RPKM 10.9) and 20 other tissues.

Summary

Predicted to enable actin binding activity and small GTPase binding activity. Predicted to be involved in nervous system development and regulation of Wnt signaling pathway. Predicted to act upstream of or within determination of left/right symmetry. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

DAAM2 Products (2)

mRNA	Protein	Name
NM_001201427.2	NP_001188356.1	disheveled-associated activator of morphogenesis 2 isoform 1
NM_015345.4	NP_056160.2	disheveled-associated activator of morphogenesis 2 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	33232676	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in podocyte cell migration	IDA IDA: Inferred from direct assay	33232676	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	24223803	GOA
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	24223803	GOA
involved in regulation of actin filament polymerization	IDA IDA: Inferred from direct assay	33232676	GOA
involved in regulation of filopodium assembly	IDA IDA: Inferred from direct assay	33232676	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DAAM2 Protein Structure

Drf_GBD

Drf_FH3

FH2

0
200
400
600
800
1000
1068 a.a.

Protein Preferred Names	Protein Names
disheveled-associated activator of morphogenesis 2

Related Diseases

Diseases	Alias
Nephrotic Syndrome, Type 24	NPHS24 Idiopathic Steroid-Resistant Nephrotic Syndrome Idiopathic Srns Nephrotic Syndrome 24 Nephrotic Syndrome, Idiopathic, Steroid-Resistant Nephrotic Syndrome, Steroid-Resistant, Autosomal Recessive
Genetic Steroid-Resistant Nephrotic Syndrome	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Genetic Srns Hereditary Steroid-Resistant Nephrotic Syndrome Familial Idiopathic Nephrotic Syndrome Nephrotic Syndrome, Steroid-Resistant, Autosomal Recessive Srn1
Guillain-Barre Syndrome	Guillain-Barré Syndrome Acute Inflammatory Polyneuropathy Gbs Acute Inflammatory Demyelinating Polyneuropathy Acute Inflammatory Demyelinating Polyradiculoneuropathy Acute Infective Polyneuritis Acute Inflammatory Demyelinating Polyradiculopathy Acute Postinfectious Polyneuropathy Infectious Neuronitis Post-Infectious Polyneuritis Postinfectious Polyneuritis Acute Autoimmune Peripheral Neuropathy Acute Immune-Mediated Polyneuropathy Acute Inflammatory Neuropathy Guillain-Barré-Strohl Syndrome Landry'S Ascending Paralysis Landry-Guillain-Barre-Strohl Syndrome Post-Infective Polyneuritis Acute Infectious Polyneuritis Fisher Syndrome Landry-Guillain-Barre Syndrome Guillain-Barre-Strohl Syndrome Variant Of Guillain-Barre Syndrome Variant Of Gbs Aidp Acute Idiopathic Demyelinating Polyneuropathy Gbs, Acute Inflammatory Demyelinating Polyradiculoneuropathic Form Guillain-Barre Syndrome, Acute Inflammatory Demyelinating Polyradiculoneuropathic Form Miller Fisher Syndrome
Cerebral Amyloid Angiopathy, Itm2b-Related, 2	Dementia, Familial Danish Fdd Familial Danish Dementia Heredopathia Ophthalmootoencephalica Hooe Cerebellar Ataxia, Cataract, Deafness, And Dementia Or Psychosis Adan Amyloidosis Itm2b-Related Cerebral Amyloid Angiopathy 2 Itm2b Amyloidosis Familial Cerebral Amyloid Angiopathy Itm2b-Related Amyloidosis Itm2b-Related Cerebral Amyloid Angiopathy Familial Dementia, Danish Type Cerebral Amyloid Angiopathy, Itm2b-Related 2 CAA-ITM2B2 Cerebellar Ataxia Cataract Deafness And Dementia Or Psychosis Dementia, Familial, Danish
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Apolipoprotein C-Iii Deficiency	Hyperalphalipoproteinemia 2 HALP2
Malignant Breast Melanoma	Malignant Melanoma Of Breast Breast Melanoma
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03509	DAAM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DAAM2	VGNC	VGNC:27863
Mus musculus	DAAM2	MGD	MGI:1923691
Felis catus	DAAM2	VGNC	VGNC:61327
Macaca mulatta	DAAM2	VGNC	VGNC:71658
Rattus norvegicus	DAAM2	RGD	RGD:1306128
Canis familiaris	DAAM2	VGNC	VGNC:39757
Others	DAAM2	NCBI