2. Gene
  3. Cldn19 - claudin 19 Gene

Cldn19 - claudin 19 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 242653 | Gene type: protein coding

About Cldn19

Summary

This gene encodes a member of the Claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. siRNA knockdown of this gene in mice develops the FHHNC (familial hypomagnesemia with hypercalciuria and nephrocalcinosis) symptoms of chronic renal wasting of magnesium and calcium together with defective renal salt handling. The protein encoded by this gene interacts with another family member, Claudin 16, and their interaction is required for their assembly into tight junctions and for renal reabsorption of magnesium. This protein is a constituent of tight junctions in the Schwann cells of peripheral myelinated nerves and the gene deficiency affects the nerve conduction of peripheral myelinated fibers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]

Cldn19 Products(2)

mRNA Protein Name
NM_001038590.1 NP_001033679.1 claudin-19 isoform 1
NM_153105.7 NP_694745.1 claudin-19 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25678664 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within apical junction assembly IMP
IMP: Inferred from mutant phenotype
15883201 MGI
acts upstream of or within neuronal action potential propagation IMP
IMP: Inferred from mutant phenotype
15883201 MGI
involved in renal absorption IMP
IMP: Inferred from mutant phenotype
19706394 MGI
involved in retinal pigment epithelium development IMP
IMP: Inferred from mutant phenotype
30937396 MGI
acts upstream of or within tight junction organization IMP
IMP: Inferred from mutant phenotype
15883201 MGI
Cellular Component GO Annotation Evidence Reference Source
located in Schmidt-Lanterman incisure IDA
IDA: Inferred from direct assay
15883201 MGI
located in bicellular tight junction IDA
IDA: Inferred from direct assay
15883201 MGI
located in cell junction IDA
IDA: Inferred from direct assay
16427635 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
16427635 MGI
located in mesaxon IDA
IDA: Inferred from direct assay
15883201 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16427635 MGI
located in paranodal junction IDA
IDA: Inferred from direct assay
15883201 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
25678664 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

claudin-19

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02769 CLDN19 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cldn19 NCBI NCBI:149461