ADAM2 - ADAM metallopeptidase domain 2 Gene

Homo sapiens

Also known as CT15; FTNB; PH30; CRYN1; CRYN2; PH-30b; PH30-beta

Gene ID: 2515 | Gene type: protein coding

About ADAM2

Cytogenetic location: 8p11.22 Genomic coordinates (GRCh38): 8:39,743,735-39,838,227 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 361 orthologues and 20 paralogues. Restricted expression toward testis (RPKM 28.4).

Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded protein is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

ADAM2 Products(3)

mRNA	Protein	Name
NM_001278113.2	NP_001265042.1	disintegrin and metalloproteinase domain-containing protein 2 isoform 2 precursor
NM_001278114.2	NP_001265043.1	disintegrin and metalloproteinase domain-containing protein 2 isoform 3 precursor
NM_001464.5	NP_001455.3	disintegrin and metalloproteinase domain-containing protein 2 isoform 1 preproprotein

ADAM2 Protein Structure

Pep_M12B_propep

Reprolysin

Disintegrin

ADAM_CR

0
200
400
600
735 a.a.

Protein Preferred Names

Protein Names

disintegrin and metalloproteinase domain-containing protein 2

cancer/testis antigen 15

Related Diseases

Diseases

Alias

Meckel Syndrome, Type 3

MKS3	Meckel Syndrome 3
Meckel-Gruber Syndrome, Type 3	Meckel Syndrome Type 3

Severe Congenital Neutropenia 4

Autosomal Recessive Severe Congenital Neutropenia Due To G6pc3 Deficiency	Scn4
Severe Congenital Neutropenia-Pulmonary Hypertension-Superficial Venous Angiectasis Syndrome	Dursun Syndrome
Severe Congenital Neutropenia Type 4

Gait Apraxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00276	ADAM2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ADAM2	VGNC	VGNC:55029
Macaca mulatta	ADAM2	VGNC	VGNC:83976
Rattus norvegicus	ADAM2	RGD	RGD:69299
Mus musculus	ADAM2	MGD	MGI:1340894
Felis catus	ADAM2	VGNC	VGNC:59579

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