Slc17a8 - solute carrier family 17 member 8 Gene

Rattus norvegicus

Also known as Vglut3

Gene ID: 266767 | Gene type: protein coding

About Slc17a8

Summary

Predicted to enable L-glutamate transmembrane transporter activity and neurotransmitter transmembrane transporter activity. Involved in brain development; cochlea development; and neural retina development. Located in several cellular components, including axon; dendrite; and glial limiting end-foot. Biomarker of Parkinsonism; cochlear disease; sciatic neuropathy; transient cerebral ischemia; and trichinosis. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25. Orthologous to human SLC17A8 (solute carrier family 17 member 8). [provided by Alliance of Genome Resources, Apr 2022]

Slc17a8 Products(1)

mRNA	Protein	Name
NM_153725.2	NP_714947.1	vesicular glutamate transporter 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-glutamate uniporter activity	IDA IDA: Inferred from direct assay	12097496	RGD
enables chloride channel activity	IDA IDA: Inferred from direct assay	27133463	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in L-glutamate import	IDA IDA: Inferred from direct assay	12388773	RGD
involved in L-glutamate import	IMP IMP: Inferred from mutant phenotype	12097496	RGD
involved in L-glutamate transmembrane transport	IMP IMP: Inferred from mutant phenotype	12097496	RGD
involved in cochlea development	IEP IEP: Inferred from expression pattern	24064385	RGD
involved in neural retina development	IEP IEP: Inferred from expression pattern	18482716	RGD
involved in regulation of acetylcholine uptake	IDA IDA: Inferred from direct assay	18278042	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical dendrite	IDA IDA: Inferred from direct assay	15163690	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	12388773	RGD
located in basal dendrite	IDA IDA: Inferred from direct assay	15163690	RGD
located in dendrite	IDA IDA: Inferred from direct assay	12388773	RGD
located in excitatory synapse	IDA IDA: Inferred from direct assay	16519671	RGD
located in glial limiting end-foot	IDA IDA: Inferred from direct assay	12388773	RGD
located in multivesicular body	IDA IDA: Inferred from direct assay	12388773	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	12388773	RGD
located in pericellular basket	IDA IDA: Inferred from direct assay	18611437	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	17435391	RGD
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	12388773	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

vesicular glutamate transporter 3

solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8

solute carrier family 17 (vesicular glutamate transporter), member 8

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13041	SLC17A8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc17a8	NCBI	NCBI:246213

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