Slc17a8 - solute carrier family 17 member 8 Gene

Also Known as Vglut3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 266767

Summary

Predicted to enable L-glutamate transmembrane transporter activity and neurotransmitter transmembrane transporter activity. Involved in brain development; cochlea development; and neural retina development. Located in several cellular components, including axon; dendrite; and glial limiting end-foot. Biomarker of Parkinsonism; cochlear disease; sciatic neuropathy; transient cerebral ischemia; and trichinosis. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25. Orthologous to human SLC17A8 (solute carrier family 17 member 8). [provided by Alliance of Genome Resources, Apr 2022]

Slc17a8 Products (1)

mRNA Protein Name
NM_153725.2 NP_714947.1 vesicular glutamate transporter 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables L-glutamate uniporter activity IDA
IDA: Inferred from direct assay
12097496 RGD
enables chloride channel activity IDA
IDA: Inferred from direct assay
27133463 RGD
Biological Process GO Annotation Evidence References Source
involved in L-glutamate import IDA
IDA: Inferred from direct assay
12388773 RGD
involved in L-glutamate import IMP
IMP: Inferred from mutant phenotype
12097496 RGD
involved in L-glutamate transmembrane transport IMP
IMP: Inferred from mutant phenotype
12097496 RGD
involved in cochlea development IEP
IEP: Inferred from expression pattern
24064385 RGD
involved in neural retina development IEP
IEP: Inferred from expression pattern
18482716 RGD
involved in regulation of acetylcholine uptake IDA
IDA: Inferred from direct assay
18278042 RGD
Cellular Component GO Annotation Evidence References Source
located in apical dendrite IDA
IDA: Inferred from direct assay
15163690 RGD
located in axon terminus IDA
IDA: Inferred from direct assay
12388773 RGD
located in basal dendrite IDA
IDA: Inferred from direct assay
15163690 RGD
located in dendrite IDA
IDA: Inferred from direct assay
12388773 RGD
located in excitatory synapse IDA
IDA: Inferred from direct assay
16519671 RGD
located in glial limiting end-foot IDA
IDA: Inferred from direct assay
12388773 RGD
located in multivesicular body IDA
IDA: Inferred from direct assay
12388773 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
12388773 RGD
located in pericellular basket IDA
IDA: Inferred from direct assay
18611437 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
17435391 RGD
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
12388773 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vesicular glutamate transporter 3

  • solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8

  • solute carrier family 17 (vesicular glutamate transporter), member 8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13041 SLC17A8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc17a8 NCBI NCBI:246213