KCNMB3 - potassium calcium-activated channel subfamily M regulatory beta subunit 3 Gene

Also Known as HBETA3; KCNMB2; KCNMBL; BKBETA3; SLOBETA3; SLO-BETA-3; K(VCA)BETA-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27094

About KCNMB3

Cytogenetic location: 3q26.32 Genomic coordinates (GRCh38): 3:179,239,703-179,267,050 (from NCBI)

This gene has 7 transcripts (splice variants), 162 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 6.7), gall bladder (RPKM 6.6) and 25 other tissues.

Summary

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. [provided by RefSeq, Jul 2009]

KCNMB3 Products (5)

mRNA Protein Name
NM_001163677.2 NP_001157149.1 calcium-activated potassium channel subunit beta-3 isoform e
NM_014407.3 NP_055222.3 calcium-activated potassium channel subunit beta-3 isoform d
NM_171828.3 NP_741979.1 calcium-activated potassium channel subunit beta-3 isoform a
NM_171829.3 NP_741980.1 calcium-activated potassium channel subunit beta-3 isoform b
NM_171830.2 NP_741981.1 calcium-activated potassium channel subunit beta-3 isoform c

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium-activated potassium channel activity IDA
IDA: Inferred from direct assay
10692449 GOA
Biological Process GO Annotation Evidence References Source
involved in action potential IDA
IDA: Inferred from direct assay
10692449 GOA
involved in detection of calcium ion IDA
IDA: Inferred from direct assay
10692449 GOA
involved in neuronal action potential IDA
IDA: Inferred from direct assay
10692449 GOA
involved in potassium ion transport IDA
IDA: Inferred from direct assay
10692449 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
10692449 GOA
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
10692449 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNMB3 Protein Structure

CaKB

CaKB: Calcium-activated potassium channel, beta subunit (47 - 244)

  • 0
  • 100
  • 200
  • 279 a.a.
Protein Preferred Names Protein Names

calcium-activated potassium channel subunit beta-3

  • BK channel beta subunit 3

Related Diseases

Diseases Alias
Epilepsy, Familial Adult Myoclonic, 5

  • FAME5

  • Fcmte5

  • Cortical Myoclonic Tremor With Epilepsy, Familial, 5

  • Familial Adult Myoclonic Epilepsy 5

  • Epilepsy, Myoclonic, Familial Adult, 5

  • Familial Cortical Myoclonic Tremor And Epilepsy 5

  • Familial Cortical Myoclonic Tremor With Epilepsy 5

  • Epilepsy, Myoclonic, Familial Adult, Type 5
Familial Febrile Seizures

  • Familial Febrile Convulsions

  • Feb

  • Febrile Seizures, Familial
Severe Congenital Neutropenia 3

  • Kostmann Syndrome

  • Infantile Agranulocytosis

  • Kostmann Disease

  • Scn3

  • Severe Congenital Neutropenia Type 3
Epilepsy, Idiopathic Generalized

  • Idiopathic Generalized Epilepsy

  • Generalised Epilepsy

  • Epilepsy, Generalized

  • EIG

  • Ige

  • Epilepsy, Idiopathic Generalized, Susceptibility To, 1

  • Epilepsy, Idiopathic Generalized 1

  • Epilepsy, Idiopathic Generalized, Susceptibility To

  • Epilepsy, Idiopathic, Generalized

  • Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 1
Autosomal Dominant Nocturnal Frontal Lobe Epilepsy

  • Adnfle

  • Autosomal Dominant Sleep-Related Hypermotor Epilepsy

  • Enfl

  • Benign Familial Infantile Seizures 6

  • Benign Familial Infantile Seizures, 6

  • Nocturnal Frontal Lobe Epilepsy-4

  • Enfl1

  • Epilepsy, Nocturnal Frontal Lobe, 1

  • Epilepsy, Nocturnal Frontal Lobe, Type 1
Epilepsy, Myoclonic Juvenile

  • Juvenile Myoclonic Epilepsy

  • Janz Syndrome

  • Jme

  • Myoclonic Epilepsy, Juvenile, Susceptibility To, 1

  • EJM

  • Myoclonic Epilepsy, Juvenile

  • Petit Mal, Impulsive

  • Myoclonic Epilepsy, Juvenile 1

  • Myoclonic Epilepsy, Juvenile, 1

  • Adolescent Myoclonic Epilepsy

  • Juvenile Myoclonus Epilepsy

  • Juvenile Myoclonic Epilepsy 1

  • EJM1

  • Petit Mal Impulsive

  • Susceptibility To Juvenile Myoclonic Epilepsy 1

  • Myoclonic Epilepsy Juvenile

  • Epilepsy, Myoclonic, Juvenile

  • Myoclonic Epilepsy Of Janz

  • Jme - [Juvenile Myoclonic Epilepsy]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07167 KCNMB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus KCNMB3 MGD MGI:3612244
Felis catus KCNMB3 VGNC VGNC:102764
Macaca mulatta KCNMB3 VGNC VGNC:74000
Canis familiaris KCNMB3 VGNC VGNC:42283
Rattus norvegicus KCNMB3 RGD RGD:1311852
Bos taurus KCNMB3 VGNC VGNC:30481
Others KCNMB3 NCBI