2. Gene
  3. Plekhm1 - pleckstrin homology domain containing, family M (with RUN domain) member 1 Gene

Plekhm1 - pleckstrin homology domain containing, family M (with RUN domain) member 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as B2; AP162; D330036J23Rik

Gene ID: 353047 | Gene type: protein coding

About Plekhm1

Summary

Predicted to enable metal ion binding activity. Involved in lysosome localization; positive regulation of bone resorption; and positive regulation of ruffle assembly. Predicted to be located in autolysosome and nucleolus. Used to study autosomal recessive osteopetrosis 6. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 6 and osteopetrosis. Orthologous to human PLEKHM1 (pleckstrin homology and RUN domain containing M1). [provided by Alliance of Genome Resources, Apr 2022]

Plekhm1 Products(1)

mRNA Protein Name
NM_183034.2 NP_898855.1 pleckstrin homology domain-containing family M member 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22073305 MGI
Biological Process GO Annotation Evidence Reference Source
involved in lysosome localization IMP
IMP: Inferred from mutant phenotype
27777970 MGI
involved in positive regulation of bone resorption IMP
IMP: Inferred from mutant phenotype
27777970 MGI
involved in positive regulation of ruffle assembly IMP
IMP: Inferred from mutant phenotype
27777970 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pleckstrin homology domain-containing family M member 1

PH domain-containing family M member 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10697 PLEKHM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plekhm1 NCBI NCBI:9842