Kif1a - kinesin family member 1A Gene

Rattus norvegicus

Gene ID: 363288 | Gene type: protein coding

About Kif1a

Summary

Enables identical protein binding activity and microtubule binding activity. Involved in several processes, including interkinetic nuclear migration; regulation of dendritic spine morphogenesis; and transport along microtubule. Located in several cellular components, including microtubule; neuronal cell body; and secretory vesicle. Is extrinsic component of neuronal dense core vesicle membrane. Part of protein-containing complex. Biomarker of synucleinopathy. Human ortholog(s) of this gene implicated in NESCAV syndrome; hereditary sensory neuropathy; hereditary sensory neuropathy type 2C; hereditary spastic paraplegia; and hereditary spastic paraplegia 30. Orthologous to human KIF1A (Kinesin family member 1A). [provided by Alliance of Genome Resources, Apr 2022]

Kif1a Products(1)

mRNA	Protein	Name
NM_001408926.1	NP_001395855.1	kinesin-like protein KIF1A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	19338388	RGD
enables microtubule binding	IDA IDA: Inferred from direct assay	19338388	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	23245325	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in anterograde axonal transport	IMP IMP: Inferred from mutant phenotype	23245325	RGD
involved in anterograde dendritic transport	IDA IDA: Inferred from direct assay	30021165	RGD
involved in anterograde dendritic transport	IMP IMP: Inferred from mutant phenotype	30021165	RGD
involved in anterograde neuronal dense core vesicle transport	IGI IGI: Inferred from genetic interaction	28426968	RGD
involved in dense core granule cytoskeletal transport	IMP IMP: Inferred from mutant phenotype	29166604	RGD
involved in interkinetic nuclear migration	IMP IMP: Inferred from mutant phenotype	21037580	RGD
involved in protein transport along microtubule	IDA IDA: Inferred from direct assay	19338388	RGD
involved in regulation of dendritic spine development	IMP IMP: Inferred from mutant phenotype	30021165	RGD
involved in regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	30021165	RGD
involved in retrograde neuronal dense core vesicle transport	IGI IGI: Inferred from genetic interaction	28426968	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	12522103	RGD
located in axon	IMP IMP: Inferred from mutant phenotype	29166604	RGD
located in dendrite	IDA IDA: Inferred from direct assay	12522103	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	30021165	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	30021165	RGD
located in microtubule	IDA IDA: Inferred from direct assay	12522103	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	19338388	RGD
located in neuronal dense core vesicle	IDA IDA: Inferred from direct assay	29166604	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	30021165	RGD
located in postsynapse	IDA IDA: Inferred from direct assay	12522103	RGD
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	30021165	RGD
located in presynapse	IDA IDA: Inferred from direct assay	12522103	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	12522103	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	12522103	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

kinesin-like protein KIF1A

axonal transport of synaptic vesicles-like

neuron-specific kinesin motor KIF1A

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07269	KIF1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kif1a	NCBI	NCBI:547

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