Pjvk - pejvakin Gene

Mus musculus

Also known as Dfnb59; Gm1001

Gene ID: 381375 | Gene type: protein coding

About Pjvk

Summary

Involved in several processes, including pexophagy; programmed cell death in response to reactive oxygen species; and regulation of peroxisome organization. Acts upstream of or within cell death; detection of mechanical stimulus involved in sensory perception of sound; and stereocilium maintenance. Located in several cellular components, including cytoskeleton; peroxisomal membrane; and stereocilium base. Used to study autosomal recessive nonsyndromic deafness 59. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 59. Orthologous to human PJVK (pejvakin). [provided by Alliance of Genome Resources, Apr 2022]

Pjvk Products(1)

mRNA	Protein	Name
NM_001080711.2	NP_001074180.1	pejvakin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28089576	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within detection of mechanical stimulus involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	28089576	MGI
involved in pexophagy	IMP IMP: Inferred from mutant phenotype	30936319	MGI
involved in programmed cell death in response to reactive oxygen species	IMP IMP: Inferred from mutant phenotype	30936319	MGI
involved in regulation of peroxisome organization	IMP IMP: Inferred from mutant phenotype	26544938	MGI
involved in response to reactive oxygen species	IMP IMP: Inferred from mutant phenotype	30936319	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	16804542	MGI
involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	26544938	MGI
acts upstream of or within stereocilium maintenance	IMP IMP: Inferred from mutant phenotype	28209736	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in ciliary rootlet	IDA IDA: Inferred from direct assay	28209736	MGI
located in cortical actin cytoskeleton	IDA IDA: Inferred from direct assay	28089576	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	28209736	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	16804542	MGI
located in peroxisomal membrane	IDA IDA: Inferred from direct assay	26544938	MGI
located in stereocilium base	IDA IDA: Inferred from direct assay	28209736	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pejvakin

autosomal recessive deafness type 59 protein homolog	deafness, autosomal recessive 59
protein sirtaki

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10590	PJVK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pjvk	NCBI	NCBI:494513

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