MIR134 - microRNA 134 Gene

Also Known as MIRN134; mir-134

Species: Homo sapiens

Gene Type: ncRNA

Gene ID: 406924

About MIR134

Cytogenetic location: 14q32.31 Genomic coordinates (GRCh38): 14:101,054,687-101,054,759 (from NCBI)

This gene has 1 transcript (splice variant) and 20 orthologues.

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	27558843	GOA
enables mRNA base-pairing translational repressor activity	IDA IDA: Inferred from direct assay	26512644	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in miRNA-mediated gene silencing by inhibition of translation	IDA IDA: Inferred from direct assay	26512644	GOA
involved in miRNA-mediated post-transcriptional gene silencing	IDA IDA: Inferred from direct assay	27558843	GOA
involved in negative regulation of cardiac muscle myoblast proliferation	IMP IMP: Inferred from mutant phenotype	26512644	GOA
involved in negative regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	26512644	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

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Diabetes Mellitus	Diabetes
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 1	Calpainopathy Lgmd2a Muscular Dystrophy, Limb-Girdle, Type 2a Lgmd2 Muscular Dystrophy, Pelvofemoral LGMDR1 Muscular Dystrophy, Limb-Girdle, Type 2 Leyden-Moebius Muscular Dystrophy Limb-Girdle Muscular Dystrophy Type 2a Muscular Dystrophy Limb Girdle Type 2a, Erb Type Limb-Girdle Muscular Dystrophy, Type 2e Limb-Girdle Muscular Dystrophy Type 2 Limb-Girdle Muscular Dystrophy Type 2e Beta-Sarcoglycan Limb-Girdle Muscular Dystrophy Lgmd2e Muscular Dystrophy Limb-Girdle With Beta-Sarcoglycan Deficiency Leyden-Moebious Muscular Dystrophy Limb-Girdle Muscular Dystrophy 2a Limb-Girdle Muscular Dystrophy, Type 2a Limb-Girdle Muscular Dystrophy, Type 2s Dystrophy, Muscular, Limb-Girdle, Type 2e Dystrophy, Muscular, Limb-Girdle, Type 2s Muscular Dystrophy, Limb-Girdle, Type 2s Beta-Sarcoglycanopathy
Nemaline Myopathy	Rod Myopathy Nemaline Body Disease Nemaline Rod Myopathy Myopathies, Nemaline Nm Nemaline Rod Disease Rod Body Disease Rod-Body Myopathy Myopathy, Nemaline Congenital Rod Disease Nem Nemaline Bodies Myopathies Nemaline
Muscular Dystrophy, Duchenne Type	Duchenne Muscular Dystrophy DMD Muscular Dystrophy, Duchenne Muscular Dystrophy, Pseudohypertrophic Progressive, Duchenne Type Severe Dystrophinopathy, Duchenne Type Muscular Dystrophy Duchenne Dystrophy, Muscular, Duchenne Type Benign Duchenne Muscular Dystrophy Duchenne Motor Neuron Disease Duchenne Type Dystrophy Duchenne-Griesinger Disease
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
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Autoimmune Disease Of Central Nervous System
Female Reproductive System Disease	Genital Diseases, Female Female Reproductive System Disorder
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
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Central Nervous System Disease	Cns Disorder CNS Cns Diseases Central Nervous System Diseases
Demyelinating Disease	Demyelinating Diseases Demyelinating Disorder
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Respiratory System Disease	Abnormality Of The Respiratory System Respiration Disorders Respiratory Tract Diseases
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Purity	Rare Diseases
HY-R00256	hsa-miR-134-5p mimic	94.77%	Unkown
HY-R04607	hsa-miR-134-3p mimic	93.71%	Unkown
HY-R00256A	hsa-miR-134-5p agomir	/	Unkown
HY-R02668	mmu-miR-134-3p mimic	/	Unkown
HY-R02668A	mmu-miR-134-3p agomir	/	Unkown
HY-R04229	rno-miR-134-3p mimic	/	Unkown
HY-R04229A	rno-miR-134-3p agomir	/	Unkown
HY-R04607A	hsa-miR-134-3p agomir	/	Unkown
HY-RI00256	hsa-miR-134-5p inhibitor	/	Unkown
HY-RI00256A	hsa-miR-134-5p antagomir	/	Unkown
HY-RI02668	mmu-miR-134-3p inhibitor	/	Unkown
HY-RI02668A	mmu-miR-134-3p antagomir	/	Unkown
HY-RI04229	rno-miR-134-3p inhibitor	/	Unkown
HY-RI04229A	rno-miR-134-3p antagomir	/	Unkown
HY-RI04607	hsa-miR-134-3p inhibitor	/	Unkown
HY-RI04607A	hsa-miR-134-3p antagomir	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MIR134	RGD	RGD:2325429
Mus musculus	MIR134	MGD	MGI:2676819