Atp8a2 - ATPase, aminophospholipid transporter-like, class I, type 8A, member 2 Gene

Mus musculus

Also known as wl; agil; Atpc1b

Gene ID: 50769 | Gene type: protein coding

About Atp8a2

Summary

Enables aminophospholipid flippase activity. Involved in several processes, including detection of light stimulus involved in visual perception; positive regulation of cellular component organization; and sensory organ morphogenesis. Acts upstream of or within several processes, including eating behavior; involuntary skeletal muscle contraction; and neuromuscular process controlling posture. Located in Golgi apparatus; endosome; and membrane. Is expressed in several structures, including nervous system; salivary gland; sensory organ; testis; and thymus. Used to study cerebellar ataxia, mental retardation and dysequlibrium syndrome. Human ortholog(s) of this gene implicated in cerebellar ataxia, mental retardation and dysequlibrium syndrome. Orthologous to human ATP8A2 (ATPase phospholipid transporting 8A2). [provided by Alliance of Genome Resources, Apr 2022]

Atp8a2 Products(1)

mRNA	Protein	Name
NM_015803.3	NP_056618.1	phospholipid-transporting ATPase IB

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables aminophospholipid flippase activity	IMP IMP: Inferred from mutant phenotype	22912588	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within axonogenesis	IMP IMP: Inferred from mutant phenotype	1634998	MGI
involved in detection of light stimulus involved in visual perception	IMP IMP: Inferred from mutant phenotype	24413176	MGI
acts upstream of or within determination of adult lifespan	IMP IMP: Inferred from mutant phenotype	1634998	MGI
acts upstream of or within eating behavior	IMP IMP: Inferred from mutant phenotype	1634998	MGI
involved in inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	24413176	MGI
acts upstream of or within involuntary skeletal muscle contraction	IMP IMP: Inferred from mutant phenotype	1634998	MGI
involved in neurofilament cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	22912588	MGI
acts upstream of or within neuromuscular process controlling posture	IMP IMP: Inferred from mutant phenotype	1634998	MGI
acts upstream of or within neuron development	IMP IMP: Inferred from mutant phenotype	1634998	MGI
acts upstream of or within positive regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	1634998	MGI
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	22641037	MGI
involved in positive regulation of phospholipid translocation	IDA IDA: Inferred from direct assay	22912588	MGI
involved in response to auditory stimulus	IMP IMP: Inferred from mutant phenotype	24413176	MGI
involved in retina layer formation	IMP IMP: Inferred from mutant phenotype	24413176	MGI
acts upstream of or within skin development	IMP IMP: Inferred from mutant phenotype	1634998	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	24413176	MGI
located in endosome	IDA IDA: Inferred from direct assay	24413176	MGI
located in membrane	IDA IDA: Inferred from direct assay	22912588	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

phospholipid-transporting ATPase IB

ATPase 8A2, class I	ATPase 8A2, p type
ATPase class I type 8A member 2	ATPase, class 1, member a
P4-ATPase flippase complex alpha subunit ATP8A2	probable phospholipid-transporting ATPase IB

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01238	ATP8A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atp8a2	NCBI	NCBI:51761

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