Slc7a8 - solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 Gene

Also Known as LAT2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 50934

Summary

Enables glycine transmembrane transporter activity and thyroid hormone transmembrane transporter activity. Involved in amino acid transport and thyroid hormone transport. Acts upstream of or within L-amino acid transport. Located in apical plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Used to study sensorineural hearing loss. Orthologous to human SLC7A8 (solute carrier family 7 member 8). [provided by Alliance of Genome Resources, Apr 2022]

Slc7a8 Products (1)

mRNA Protein Name
NM_016972.2 NP_058668.1 large neutral amino acids transporter small subunit 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables L-amino acid transmembrane transporter activity IDA
IDA: Inferred from direct assay
15659399 MGI
enables glycine transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
32046769 MGI
enables neutral L-amino acid transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
32046769 MGI
enables thyroid hormone transmembrane transporter activity IDA
IDA: Inferred from direct assay
26601072 MGI
enables thyroid hormone transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
21264952 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within L-amino acid transport IDA
IDA: Inferred from direct assay
15659399 MGI
involved in L-leucine transport IMP
IMP: Inferred from mutant phenotype
32046769 MGI
involved in glycine transport IMP
IMP: Inferred from mutant phenotype
32046769 MGI
involved in proline transmembrane transport IMP
IMP: Inferred from mutant phenotype
32046769 MGI
involved in thyroid hormone transport IDA
IDA: Inferred from direct assay
26601072 MGI
involved in thyroid hormone transport IMP
IMP: Inferred from mutant phenotype
21264952 MGI
involved in tryptophan transport IMP
IMP: Inferred from mutant phenotype
32046769 MGI
involved in valine transport IMP
IMP: Inferred from mutant phenotype
32046769 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
32046769 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

large neutral amino acids transporter small subunit 2

  • L-type amino acid transporter 2

  • mLAT2

  • solute carrier family 7 member 8

  • solute carrier family 8 (cationic amino acid transporter, y+ system), member 7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-133677 Mono(2-ethyl-5-hydroxyhexyl) phthalate 99.03% Unkown
HY-RS13335 SLC7A8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc7a8 NCBI NCBI:23428