Slc7a8 - solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 Gene

Mus musculus

Also known as LAT2

Gene ID: 50934 | Gene type: protein coding

About Slc7a8

Summary

Enables glycine transmembrane transporter activity and thyroid hormone transmembrane transporter activity. Involved in amino acid transport and thyroid hormone transport. Acts upstream of or within L-amino acid transport. Located in apical plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Used to study sensorineural hearing loss. Orthologous to human SLC7A8 (solute carrier family 7 member 8). [provided by Alliance of Genome Resources, Apr 2022]

Slc7a8 Products(1)

mRNA	Protein	Name
NM_016972.2	NP_058668.1	large neutral amino acids transporter small subunit 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-amino acid transmembrane transporter activity	IDA IDA: Inferred from direct assay	15659399	MGI
enables glycine transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	32046769	MGI
enables neutral L-amino acid transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	32046769	MGI
enables thyroid hormone transmembrane transporter activity	IDA IDA: Inferred from direct assay	26601072	MGI
enables thyroid hormone transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	21264952	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within L-amino acid transport	IDA IDA: Inferred from direct assay	15659399	MGI
involved in L-leucine transport	IMP IMP: Inferred from mutant phenotype	32046769	MGI
involved in glycine transport	IMP IMP: Inferred from mutant phenotype	32046769	MGI
involved in proline transmembrane transport	IMP IMP: Inferred from mutant phenotype	32046769	MGI
involved in thyroid hormone transport	IDA IDA: Inferred from direct assay	26601072	MGI
involved in thyroid hormone transport	IMP IMP: Inferred from mutant phenotype	21264952	MGI
involved in tryptophan transport	IMP IMP: Inferred from mutant phenotype	32046769	MGI
involved in valine transport	IMP IMP: Inferred from mutant phenotype	32046769	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	32046769	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

large neutral amino acids transporter small subunit 2

L-type amino acid transporter 2	mLAT2
solute carrier family 7 member 8	solute carrier family 8 (cationic amino acid transporter, y+ system), member 7

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-133677	Mono(2-ethyl-5-hydroxyhexyl) phthalate		99.03%	Unkown
HY-RS13335	SLC7A8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc7a8	NCBI	NCBI:23428

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