RFNG - RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5986

About RFNG

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,047,902-82,051,811 (from NCBI)

This gene has 12 transcripts (splice variants), 215 orthologues and 3 paralogues. Ubiquitous expression in ovary (RPKM 13.6), fat (RPKM 12.9) and 25 other tissues.

Summary

Predicted to enable O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. Predicted to be involved in regulation of Notch signaling pathway. Predicted to act upstream of or within positive regulation of Notch signaling pathway and positive regulation of protein binding activity. Predicted to be integral component of Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]

RFNG Products (1)

mRNA	Protein	Name
NM_002917.2	NP_002908.1	beta-1,3-N-acetylglucosaminyltransferase radical fringe precursor

RFNG Protein Structure

Fringe

0
100
200
300
331 a.a.

Protein Preferred Names	Protein Names
beta-1,3-N-acetylglucosaminyltransferase radical fringe	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Related Diseases

Diseases	Alias
Congenital Muscular Dystrophy-Dystroglycanopathy Type A11	Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies Type A11 Mddga11 Walker-Warburg Syndrome Or Muscle-Eye-Brain Disease B3galnt2-Related Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies, Type A11
Spondylocostal Dysostosis	Jarcho-Levin Syndrome Costovertebral Dysplasia Spondylothoracic Dysostosis Spondylothoracic Dysplasia Scdo Dysostosis, Spondylocostal
Dowling-Degos Disease	Reticular Pigment Anomaly Of Flexures Dark Dot Disease Reticulate Acropigmentation Of Kitamura Dowling-Degos Kitamura Disease Kitamura Reticulate Acropigmentation Ddd Dowling-Degos-Kitamura Disease Reticular Pigmented Anomaly Of Flexures
Adams-Oliver Syndrome	Adams Oliver Syndrome Aos Congenital Scalp Defects With Distal Limb Reduction Anomalies Aplasia Cutis Congenita With Terminal Transverse Limb Defects Congenital Scalp Defects With Distal Limb Anomalies Limb, Scalp And Skull Defects Limb Scalp And Skull Defects Absence Defect Of Limbs, Scalp, And Skull

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11875	RFNG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20333	Rfng Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26841	Rfng Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RFNG	VGNC	VGNC:69299
Rattus norvegicus	RFNG	RGD	RGD:621322
Canis familiaris	RFNG	VGNC	VGNC:45499
Macaca mulatta	RFNG	VGNC	VGNC:76905
Mus musculus	RFNG	MGD	MGI:894275
Bos taurus	RFNG	VGNC	VGNC:55866
Others	RFNG	NCBI