2. Gene
  3. Scnm1 - sodium channel modifier 1 Gene

Scnm1 - sodium channel modifier 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Scnm1-ps; 3110001I17Rik

Gene ID: 69269 | Gene type: protein coding

About Scnm1

Summary

Mutations in the voltage-gated Sodium Channel gene Scn8a lead to neurological problems in mice. For one particular mutation, Scn8amedJ, mice live to adulthood but have tremors and muscle weakness, among Other problems, in all strains except those derived from C57BL6 mice. In these strains, the product of the Scnm1 gene (229 aa) partially overcomes the effects of the Scn8amedJ mutation. However, in C57BL6-derived mice, a one nt change in the penultimate exon creates a premature stop codon, truncating the Scnm1 protein at 186 aa. This truncated protein lacks the ability to overcome the effects of the Scn8amedJ mutation, and these mice suffer paralysis and juvenile death. [provided by RefSeq, Jul 2009]

Scnm1 Products(1)

mRNA Protein Name
NM_001409852.1 NP_001396781.1 sodium channel modifier 1
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within RNA splicing IMP
IMP: Inferred from mutant phenotype
12920299 MGI
involved in alternative mRNA splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
17656373 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nuclear speck IDA
IDA: Inferred from direct assay
17656373 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12920299 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium channel modifier 1

sodium channel modifier 1, pseudogene

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12551 SCNM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scnm1 NCBI NCBI:79005