VPREB1 - V-set pre-B cell surrogate light chain 1 Gene

Also Known as IGI; IGVPB; VPREB; CD179a

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7441

About VPREB1

Cytogenetic location: 22q11.22 Genomic coordinates (GRCh38): 22:22,244,786-22,245,515 (from NCBI)

This gene has 2 transcripts (splice variants), 101 orthologues and 93 paralogues.

Summary

The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

VPREB1 Products (2)

mRNA Protein Name
NM_001303509.2 NP_001290438.1 immunoglobulin iota chain isoform 2
NM_007128.4 NP_009059.1 immunoglobulin iota chain isoform 1 precursor

VPREB1 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (24 - 120)

  • 0
  • 100
  • 145 a.a.
Protein Preferred Names Protein Names

immunoglobulin iota chain

  • CD179 antigen-like family member A

VPREB1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84071 CD179A Antibody (YA3768) FC, ELISA Human
HY-P84071A CD179A Antibody (YA3768)(PBS only) FC, ELISA Human

Related Diseases

Diseases Alias
Mu Chain Disease

  • Mu-Chain Disease
Phonagnosia
Lambda 5 Deficiency
Common Variable Immunodeficiency

  • Cvid

  • Common Variable Agammaglobulinemia

  • Common Variable Immune Deficiency

  • Acquired Hypogammaglobulinemia

  • Hypogamma-Globulinemia, Acquired

  • Idiopathic Immunoglobulin Deficiency

  • Primary Antibody Deficiency

  • Primary Hypogammaglobulinemia

  • Acquired Agammaglobulinemia

  • Sporadic Hypogammaglobulinemia

  • Common Variable Hypogamma-Globulinemia

  • Immunoglobulin Deficiency, Late-Onset

  • Common Variable Hypogammaglobulinemia

  • Immunodeficiency, Common Variable
Agammaglobulinemia

  • Hypogammaglobulinemia

  • Ighm

  • Mu Heavy Chain Deficiency

  • Mu-Heavy Chain Disease

  • Mu-Hcd

  • Mu-Chain Disease
Jackson-Weiss Syndrome

  • JWS

  • Craniosynostosis, Midfacial Hypoplasia, And Foot Abnormalities

  • Craniosynostosis-Midfacial Hypoplasia-Foot Abnormalities Syndrome

  • Craniosynostosis-Midfacial Hypoplasia-Foot Abnormalities
Crouzon Syndrome

  • Crouzon Craniofacial Dysostosis

  • Craniofacial Dysostosis

  • Cfd1

  • Craniofacial Dysostosis Type 1

  • Crouzon Disease

  • Crouzon'S Disease

  • Craniofacial Dysostosis, Type I

  • Craniofacial Dysarthrosis

  • Craniofacial Dysostosis Syndrome

  • CS

  • Craniofacial Dysostosis Type I

  • Vogt Cephalosyndactyly
B-Lymphoblastic Leukemia/Lymphoma With Iamp21

  • B-All With Iamp21

  • Intrachromosomal Amplification Of Chromosome 21
Heavy Chain Disease

  • Hcd
Muenke Syndrome

  • Muenke Nonsyndromic Coronal Craniosynostosis

  • Fgfr3-Related Craniosynostosis

  • Fgfr3-Associated Coronal Synostosis

  • Coronal Craniosynostosis

  • MNKES

  • Syndrome Of Coronal Craniosynostosis

  • MNKS

  • Fgfr3-Related Isolated Coronal Synostosis

  • Muenke Non-Syndromic Coronal Craniosynostosis
Agammaglobulinemia 4, Autosomal Recessive

  • Agammaglobulinemia 4

  • AGM4

  • Agammaglobulinemia, Autosomal Recessive, Due To Blnk Defect

  • B Cell Linker Protein Deficiency

  • B-Cell Linker Protein Deficiency

  • Blnk Deficiency

  • Agammaglobulinemia Autosomal Recessive Due To Blnk Defect

  • Agammaglobulinemia, Type 4, Autosomal Recessive
Cardiomyopathy, Familial Hypertrophic, 1

  • Asymmetric Septal Hypertrophy

  • Familial Hypertrophic Cardiomyopathy

  • Hypertrophic Cardiomyopathy 1

  • CMH1

  • Hypertrophic Cardiomyopathy 19

  • CMH

  • Ventricular Hypertrophy, Hereditary

  • Ash

  • Hypertrophic Subaortic Stenosis, Idiopathic

  • Cardiomyopathy, Familial Hypertrophic

  • Cardiomyopathy, Hypertrophic, 1, Digenic

  • Cardiomyopathy, Familial Hypertrophic 1

  • Hcm

  • Hereditary Ventricular Hypertrophy

  • Idiopathic Hypertrophic Subaortic Stenosis

  • Hypertrophic Cardiomyopathy

  • Cardiomyopathy, Hypertrophic, Familial

  • Cardiomyopathy, Hypertrophic, 1

  • Familial Asymmetric Septal Hypertrophy

  • Heritable Hypertrophic Cardiomyopathy

  • Fhc

  • Cardiomyopathy, Hypertrophic, Familial, Type 1
Leukemia, Acute Lymphoblastic

  • Acute Lymphoblastic Leukemia

  • ALL

  • Acute Lymphocytic Leukemia

  • Leukemia, Acute Lymphocytic, Susceptibility To, 1

  • Acute Lymphoblastic Leukaemia

  • Precursor Lymphoblastic Lymphoma/Leukemia

  • Precursor Lymphoid Neoplasm

  • Leukemia, Acute Lymphoblastic, Susceptibility To

  • B-Cell Acute Lymphoblastic Leukemia

  • Leukemia, Acute Lymphocytic 1

  • Acute Lymphocytic Leukaemia

  • Acute Lymphoblastic Leukemia/Lymphoma

  • All1

  • Childhood Acute Lymphoblastic Leukemia

  • Leukemia Acute Lymphoblastic 1

  • Leukemia Acute Lymphoblastic B-Hyperdiploid

  • Leukemia Acute Lymphocytic

  • Leukemia Acute Lymphocytic 1

  • Leukemia B-Cell Acute Lymphoblastic

  • Leukemia T-Cell Acute Lymphoblastic

  • Leukemia, Acute Lymphoblastic, 3

  • ALL3

  • Lymphoblastic Leukemia Acute

  • Leukemia, Acute, Lymphoblastic

  • Precursor Cell Lymphoblastic Leukemia Lymphoma

  • Leukemia, Lymphocytic, Acute, L1

  • Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Hemoglobin H Disease

  • HBH

  • Hemoglobin H Disease, Nondeletional

  • Hemoglobin H Disease, Deletional

  • Alpha-Thalassemia Intermedia

  • Haemoglobin H Disease

  • Alpha-Thalassemia, Hemoglobin H Type

  • Hemoglobin H Disease, Deletional And Nondeletional

  • Alpha Thalassemia, Haemoglobin H Type

  • Alpha Thalassemia, Hemoglobin H Type

  • Haemoglobin H Disease, Deletional

  • Hbh Disease

  • Alpha-Thalassemia Hemoglobin H Type

  • Hemoglobin H Disease Deletional

  • Hemoglobin H Disease Non-Deletional

  • Alpha-Thalassemia

  • Alpha - /- - Or Mutational Forms Of Alpha-Thalassaemia

  • Alpha Thalassaemia Intermedia
Craniosynostosis

  • Premature Closure Of Cranial Sutures

  • Craniostenosis

  • Craniosynostosis Syndrome

  • Cso

  • Craniosynostoses

  • Congenital Ossification Of Cranial Sutures

  • Congenital Ossification Of Sutures Of Skull

  • Craniostosis

  • Imperfect Fusion Of Skull

  • Congenital Imperfect Closure Skull

  • Imperfect Closure Skull

  • Premature Closure Cranium Sutures

  • Deficiency Of Craniofacial Axis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15669 VPREB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus VPREB1 RGD RGD:1588558
Mus musculus VPREB1 MGD MGI:98936