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NEMF - nuclear export mediator factor Gene

Also Known as RQC2; IDDSAPN; NY-CO-1; SDCCAG1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9147

About NEMF

Cytogenetic location: 14q21.3 Genomic coordinates (GRCh38): 14:49,782,083-49,852,788 (from NCBI)

This gene has 15 transcripts (splice variants), 203 orthologues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 12.2), thyroid (RPKM 10.8) and 25 other tissues.

Summary

This gene encodes a component of the ribosome quality control complex. The encoded protein facilitates the recognition and ubiquitination of stalled 60S subunits by the ubiquitin Ligase listerin. A similar protein in fly functions as a tumor suppressor. [provided by RefSeq, Jul 2016]

NEMF Products (2)

mRNA	Protein	Name
NM_001301732.3	NP_001288661.2	ribosome quality control complex subunit NEMF isoform 2
NM_004713.6	NP_004704.3	ribosome quality control complex subunit NEMF isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables alpha-aminoacyl-tRNA binding	IDA IDA: Inferred from direct assay	33406423	GOA
enables ribosomal large subunit binding	IDA IDA: Inferred from direct assay	25578875	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in CAT tailing	IDA IDA: Inferred from direct assay	33406423	GOA
involved in nuclear export	IMP IMP: Inferred from mutant phenotype	16103875	GOA
involved in protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	25578875	GOA
involved in rescue of stalled ribosome	IDA IDA: Inferred from direct assay	25578875	GOA
involved in ribosome-associated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	25578875	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RQC complex	IDA IDA: Inferred from direct assay	25578875	GOA
located in cytosol	IDA IDA: Inferred from direct assay	25578875	GOA
is active in cytosolic ribosome	IDA IDA: Inferred from direct assay	25578875	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEMF Protein Structure

FbpA

DUF814

DUF3441

0
200
400
600
800
1000
1076 a.a.

Protein Preferred Names	Protein Names
ribosome quality control complex subunit NEMF	New-York Colon 1

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder With Speech Delay And Axonal Peripheral Neuropathy	IDDSAPN Intellectual Developmental Disorder, Speech Delay, Axonal Peripheral Neuropathy
Autosomal Recessive Non-Syndromic Intellectual Disability	Ar-Nsid Ns-Arid
Charcot-Marie-Tooth Disease, Axonal, Type 2e	Charcot-Marie-Tooth Disease Type 2 CMT2E CMT2S CMT2Y Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease Axonal Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2s Charcot-Marie-Tooth Disease, Type 2e Hereditary Motor And Sensory Neuropathy Type 2 Charcot-Marie-Tooth Neuropathy, Type 2s Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2y Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y Charcot-Marie-Tooth Neuropathy, Type 2y Charcot-Marie-Tooth Disease, Type 2y Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Neuropathy Type 2e Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation Cmt2 Due To Vcp Mutation Charcot-Marie-Tooth Disease Type 2s Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Cmt2 Charcot-Marie-Tooth Neuropathy, Type 2e Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type Hereditary Motor And Sensory Neuropathy Okinawa Type Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y Charcot-Marie-Tooth Neuropathy Type 2y Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s Charcot-Marie-Tooth Neuropathy Type 2s Charcot-Marie-Tooth Type 2 Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease 2e Charcot-Marie-Tooth Disease Axonal Type 2e Charcot-Marie-Tooth Disease Neuronal Type 2e Charcot-Marie-Tooth Disease 2s Charcot-Marie-Tooth Neuropathy Axonal Type 2s Charcot-Marie-Tooth Disease 2y Charcot-Marie-Tooth Disease, Type 2 Hereditary Motor And Sensory-Neuropathy Type Ii
Axonal Neuropathy
Polymicrogyria, Bilateral Temporooccipital	Bilateral Parasagittal Parieto-Occipital Polymicrogyria BTOP Bilateral Temporooccipital Polymicrogyria Polymicrogyria
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09206	NEMF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NEMF	MGD	MGI:1918305
Macaca mulatta	NEMF	VGNC	VGNC:84407
Canis familiaris	NEMF	VGNC	VGNC:43741
Bos taurus	NEMF	VGNC	VGNC:32004
Felis catus	NEMF	VGNC	VGNC:63775
Rattus norvegicus	NEMF	RGD	RGD:2315525
Others	NEMF	NCBI