SERINC5 - serine incorporator 5 Gene

Also Known as TPO1; C5orf12

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 256987

About SERINC5

Cytogenetic location: 5q14.1 Genomic coordinates (GRCh38): 5:80,111,225-80,256,048 (from NCBI)

This gene has 6 transcripts (splice variants), 215 orthologues and 4 paralogues. Broad expression in testis (RPKM 21.2), colon (RPKM 21.1) and 24 other tissues.

Summary

Predicted to enable L-serine transmembrane transporter activity. Involved in defense response to virus; detection of virus; and innate immune response. Located in several cellular components, including centrosome; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SERINC5 Products (3)

mRNA Protein Name
NM_001174071.3 NP_001167542.1 serine incorporator 5 isoform 3
NM_001174072.3 NP_001167543.1 serine incorporator 5 isoform 1
NM_178276.7 NP_840060.1 serine incorporator 5 isoform 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in defense response to virus IDA
IDA: Inferred from direct assay
26416733 GOA
involved in detection of virus IDA
IDA: Inferred from direct assay
26416733 GOA
involved in innate immune response IDA
IDA: Inferred from direct assay
26416733 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
26416733 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SERINC5 Protein Structure

Serinc

Serinc: Serine incorporator (Serinc) (11 - 412)

(435 - 456)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 456 a.a.
Protein Preferred Names Protein Names

serine incorporator 5

Related Diseases

Diseases Alias
Hawkinsinuria

  • 4-Alpha-Hydroxyphenylpyruvate Hydroxylase Deficiency

  • 4-Hppd Deficiency

  • 4-Hydroxyphenylpyruvic Acid Dioxygenase Deficiency

  • HWKS

  • HAWK
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12693 SERINC5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SERINC5 VGNC VGNC:34463
Rattus norvegicus SERINC5 RGD RGD:621571
Mus musculus SERINC5 MGD MGI:2444223
Canis familiaris SERINC5 VGNC VGNC:46022
Macaca mulatta SERINC5 VGNC VGNC:77271
Felis catus SERINC5 VGNC VGNC:65020