ITSN1 - Itsn1 intersectin 1 Gene

Also Known as Itsn; EHSH1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29491

Summary

Predicted to enable kinase activator activity; molecular adaptor activity; and proline-rich region binding activity. Involved in several processes, including positive regulation of dendritic spine development; positive regulation of transport; and regulation of modification of postsynaptic actin Cytoskeleton. Located in several cellular components, including clathrin-coated pit; dendrite; and neuronal cell body. Is active in glutamatergic synapse and postsynaptic actin Cytoskeleton. Orthologous to human ITSN1 (intersectin 1). [provided by Alliance of Genome Resources, Apr 2022]

ITSN1 Products (2)

mRNA Protein Name
NM_001136096.3 NP_001129568.1 intersectin-1 isoform a
NM_019227.2 NP_062100.2 intersectin-1 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10373452 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of caveolin-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
19258322 RGD
involved in positive regulation of dendritic spine development IMP
IMP: Inferred from mutant phenotype
19258322 RGD
involved in positive regulation of growth hormone secretion IMP
IMP: Inferred from mutant phenotype
16874303 RGD
involved in regulation of modification of postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
19258322 RGD
involved in regulation of modification of postsynaptic actin cytoskeleton IMP
IMP: Inferred from mutant phenotype
19258322 RGD
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
19258322 RGD
involved in regulation of postsynapse organization IMP
IMP: Inferred from mutant phenotype
19258322 RGD
Cellular Component GO Annotation Evidence References Source
located in apical dendrite IDA
IDA: Inferred from direct assay
12548702 RGD
located in clathrin-coated pit IDA
IDA: Inferred from direct assay
19258322 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
19258322 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
19258322 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
19258322 RGD
located in intracellular vesicle IDA
IDA: Inferred from direct assay
12548702 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
12548702 RGD
is active in postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
19258322 RGD
is active in postsynaptic endocytic zone IDA
IDA: Inferred from direct assay
35072626 RGD
is active in postsynaptic endocytic zone IMP
IMP: Inferred from mutant phenotype
35072626 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

intersectin-1

  • EH domain and SH3 domain regulator of endocytosis 1

  • intersectin 1 (SH3 domain protein 1A)

  • intersectin 1 (SH3 domain protein)

  • intersectin-1-like

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06997 ITSN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens ITSN1 NCBI NCBI:6453