3052947-04-0
3052947-04-0
Chemical Structure
GRK2 degrader-1
- CAS No.: 3052947-04-0
- Formula:C25H22N4O4S
- Molecular Weight:474.53
InChIKey: IDDUCAFDQHUAFX-UHFFFAOYSA-N
SMILES: O=C(CC1=CC=C2C(C(N(C3C(NC(CC3)=O)=O)C2)=O)=C1)NC4=NC=C(CC5=CC=CC=C5)S4
Biological Activity: GRK2 degrader-1 (compound 1) is a potent and orally active GRK2 degrader. GRK2 degrader-1 degrades GRK2 via the ubiquitin-proteasome pathway. GRK2 degrader-1 inhibits right ventricular remodeling and elevation of pulmonary artery pressure in a pulmonary artery hypertension (PAH) mouse model. GRK2 degrader-1 can be used for PAH research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GRK2 degrader-1 | 98.83% | GRK2 degrader-1 (compound 1) is a potent and orally active GRK2 degrader. GRK2 degrader-1 degrades GRK2 via the ubiquitin-proteasome pathway. GRK2 degrader-1 inhibits right ventricular remodeling and elevation of pulmonary artery pressure in a pulmonary artery hypertension (PAH) mouse model. GRK2 degrader-1 can be used for PAH research. | ||||||||||||||||||||
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References
Keywords
