3126270-11-6
Chemical Structure
PROTAC ATR degrader-3
- CAS No.: 3126270-11-6
- Formula:C41H38N8O6
- Molecular Weight:738.79
InChIKey: UQGVIEZTHBTZBC-KJLUBMIJSA-N
SMILES: C[C@@H]1COCCN1C2=C3C(CN(C3)C(C4=CC=C(C=C4)C(NCC5=CC=C6C(CN(C6=O)C7C(NC(CC7)=O)=O)=C5)=O)=O)=NC(C8=CC=CC9=C8C=CN9)=N2
Biological Activity: PROTAC ATR degrader-3 is a potent CRBN-based ATR PROTAC degrader with a DC50 of 127 nM. PROTAC ATR degrader-3 also degrades CHK1 with an DC50 of 135 nM. PROTAC ATR degrader-3 inhibits cancer cells proliferation, migration and invasion, triggers apoptosis and induces S phase arrest and DNA damage. PROTAC ATR degrader-3 achieves tumor growth inhibition in LoVo xenograft mouse model without apparent toxicity. PROTAC ATR degrader-3 can be used for the research of colorectal cancer[1].
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PROTAC ATR degrader-3 | PROTAC ATR degrader-3 is a potent CRBN-based ATR PROTAC degrader with a DC50 of 127 nM. PROTAC ATR degrader-3 also degrades CHK1 with an DC50 of 135 nM. PROTAC ATR degrader-3 inhibits cancer cells proliferation, migration and invasion, triggers apoptosis and induces S phase arrest and DNA damage. PROTAC ATR degrader-3 achieves tumor growth inhibition in LoVo xenograft mouse model without apparent toxicity. PROTAC ATR degrader-3 can be used for the research of colorectal cancer. | |||||||||||||||||||||
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Keywords
