NCF1 - Ncf1 neutrophil cytosolic factor 1 Gene

Also Known as Ncf-1; p47phox

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114553

Summary

Enables superoxide-generating NADPH Oxidase activator activity. Involved in several processes, including Reactive Oxygen Species biosynthetic process; regulation of respiratory burst involved in inflammatory response; and respiratory burst. Located in several cellular components, including Golgi apparatus; neuronal cell body; and rough endoplasmic reticulum. Part of NADPH Oxidase complex. Used to study rheumatoid arthritis. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome; autosomal recessive chronic granulomatous disease cytochrome b-positive type I; and chronic granulomatous disease. Orthologous to several human genes including NCF1 (neutrophil cytosolic factor 1). [provided by Alliance of Genome Resources, Apr 2022]

NCF1 Products (1)

mRNA Protein Name
NM_053734.2 NP_446186.2 neutrophil cytosolic factor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables superoxide-generating NADPH oxidase activator activity IDA
IDA: Inferred from direct assay
16040349 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
25512346 RGD
involved in cellular response to testosterone stimulus IEP
IEP: Inferred from expression pattern
25512346 RGD
involved in reactive oxygen species biosynthetic process IMP
IMP: Inferred from mutant phenotype
21275845 RGD
involved in regulation of respiratory burst involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
21275845 RGD
involved in respiratory burst IMP
IMP: Inferred from mutant phenotype
12461526 RGD
Cellular Component GO Annotation Evidence References Source
part of NADPH oxidase complex IDA
IDA: Inferred from direct assay
12241540 RGD
located in cytosol IDA
IDA: Inferred from direct assay
24445059 RGD
located in dendrite IDA
IDA: Inferred from direct assay
15804439 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15804439 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
24445059 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neutrophil cytosolic factor 1

  • neutrophil cytosol factor 1

  • neutrophil cytosol factor 1-like

  • phagocyte oxidase 47 kDa

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS20305 Ncf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09077 NCF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26813 Ncf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens NCF1 NCBI NCBI:653361