Hnf1b - HNF1 homeobox B Gene

Also Known as Tcf2; LF-B3; VHNF1; HNF-1B; HNF-1-beta

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25640

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including hepatocyte differentiation; protein-DNA complex assembly; and regulation of gene expression. Located in nucleus. Human ortholog(s) of this gene implicated in kidney disease; maturity-onset diabetes of the young type 5; pancreas disease; renal cell carcinoma; and type 2 diabetes mellitus. Orthologous to human HNF1B (HNF1 homeobox B). [provided by Alliance of Genome Resources, Apr 2022]

Hnf1b Products (3)

mRNA Protein Name
NM_001308148.1 NP_001295077.1 hepatocyte nuclear factor 1-beta isoform 1
NM_001308149.1 NP_001295078.1 hepatocyte nuclear factor 1-beta isoform 3
NM_013103.2 NP_037235.1 hepatocyte nuclear factor 1-beta isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
12860991 RGD
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
1673926 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
1673926 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
1673926 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12860991 RGD
Biological Process GO Annotation Evidence References Source
involved in circadian regulation of gene expression IDA
IDA: Inferred from direct assay
9545279 RGD
involved in embryonic morphogenesis IDA
IDA: Inferred from direct assay
12860991 RGD
involved in hepatocyte differentiation IEP
IEP: Inferred from expression pattern
18286537 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12860991 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
1673926 RGD
involved in protein-DNA complex assembly IMP
IMP: Inferred from mutant phenotype
9545279 RGD
involved in response to biphenyl IEP
IEP: Inferred from expression pattern
12051991 RGD
involved in response to carbohydrate IEP
IEP: Inferred from expression pattern
10580588 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18656965 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hepatocyte nuclear factor 1-beta

  • Transcription factor 2, hepatic

  • variant hepatic nuclear factor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06256 HNF1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174668 Human HNF1B mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hnf1b NCBI NCBI:6928