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FAM98B - family with sequence similarity 98 member B Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 283742

About FAM98B

Cytogenetic location: 15q14 Genomic coordinates (GRCh38): 15:38,454,127-38,487,710 (from NCBI)

This gene has 4 transcripts (splice variants), 100 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 11.0), endometrium (RPKM 8.6) and 25 other tissues.

Summary

Enables identical protein binding activity and protein methyltransferase activity. Involved in positive regulation of cell population proliferation; positive regulation of gene expression; and protein methylation. Located in cytoplasm and nucleoplasm. Part of tRNA-splicing Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

FAM98B Products (1)

mRNA	Protein	Name
NM_173611.4	NP_775882.2	protein FAM98B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	28040436	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24608264	GOA
enables protein methyltransferase activity	IMP IMP: Inferred from mutant phenotype	28040436	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	28040436	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	28040436	GOA
involved in protein methylation	IMP IMP: Inferred from mutant phenotype	28040436	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18445686	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24608264	GOA
part of tRNA-splicing ligase complex	IDA IDA: Inferred from direct assay	21311021	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FAM98B Protein Structure

DUF2465

0
100
200
300
330 a.a.

Protein Preferred Names	Protein Names
protein FAM98B

FAM98B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83056	FAM98B Antibody (YA2801)	WB, IHC-F, IHC-P, ICC/IF	Human
HY-P83056A	FAM98B Antibody (YA2801)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Human

Related Diseases

Diseases	Alias
Spastic Paraplegia 11, Autosomal Recessive	SPG11 Hereditary Spastic Paraplegia 11 Hsp-Tcc Autosomal Recessive Spastic Paraplegia Type 11 Nakamura-Osame Syndrome Spastic Paraplegia-Intellectual Disability-Thin Corpus Callosum Syndrome Spastic Paraplegia, Autosomal Recessive, With Mental Impairment And Thin Corpus Callosum Spastic Paraplegia, Autosomal Recessive, Complicated, With Thin Corpus Callosum Autosomal Recessive Spastic Paraplegia 11 Autosomal Recessive Spastic Paraplegia Complicated With Thin Corpus Callosum Autosomal Recessive Spastic Paraplegia With Mental Impairment And Thin Corpus Callosum Arhsp-Tcc Autosomal Recessive Spastic Paraplegia With Thinning Of Corpus Callosum Spastic Paraplegia Autosomal Recessive Complicated With Thin Corpus Callosum Spastic Paraplegia Autosomal Recessive With Mental Impairment And Thin Corpus Callosum Paraplegia, Spastic, Autosomal Recessive, Type 11 Nakamura Osame Syndrome
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04729	FAM98B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FAM98B	RGD	RGD:1564603
Macaca mulatta	FAM98B	VGNC	VGNC:72583
Mus musculus	FAM98B	MGD	MGI:1915465
Felis catus	FAM98B	VGNC	VGNC:104389
Canis familiaris	FAM98B	VGNC	VGNC:40713
Bos taurus	FAM98B	VGNC	VGNC:28849