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MLST8 - MTOR associated protein, LST8 homolog Gene

Also Known as GBL; LST8; POP3; WAT1; GbetaL

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64223

About MLST8

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,205,454-2,209,453 (from NCBI)

This gene has 35 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in testis (RPKM 10.4), brain (RPKM 8.7) and 25 other tissues.

Summary

Enables protein serine/threonine kinase activator activity. Involved in TORC1 signaling; positive regulation of TOR signaling; and regulation of actin Cytoskeleton organization. Part of TORC1 complex and TORC2 complex. [provided by Alliance of Genome Resources, Apr 2022]

MLST8 Products (7)

mRNA	Protein	Name
NM_001199173.3	NP_001186102.1	target of rapamycin complex subunit LST8 isoform a
NM_001199174.3	NP_001186103.1	target of rapamycin complex subunit LST8 isoform a
NM_001199175.3	NP_001186104.1	target of rapamycin complex subunit LST8 isoform b
NM_001352057.2	NP_001338986.1	target of rapamycin complex subunit LST8 isoform c
NM_001352059.2	NP_001338988.1	target of rapamycin complex subunit LST8 isoform d
NM_001352060.2	NP_001338989.1	target of rapamycin complex subunit LST8 isoform d
NM_022372.6	NP_071767.3	target of rapamycin complex subunit LST8 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12408816	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	12718876	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in TORC1 signaling	IMP IMP: Inferred from mutant phenotype	12718876	GOA
involved in positive regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	15467718	GOA
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	15467718	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of TORC1 complex	IDA IDA: Inferred from direct assay	12718876	GOA
part of TORC1 complex	IPI IPI: Inferred from physical interaction	26678875	GOA
part of TORC2 complex	IDA IDA: Inferred from direct assay	24036451	GOA
part of TORC2 complex	IPI IPI: Inferred from physical interaction	17461779	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MLST8 Protein Structure

WD40

0
100
200
300
326 a.a.

Protein Preferred Names	Protein Names
target of rapamycin complex subunit LST8	TORC subunit LST8

MLST8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MLST8	Q9BVC4	RPTOR	Homo sapiens	Q8N122	Anti Tag CoIP	20562859
Intra	MLST8	Q9BVC4	RPTOR	Homo sapiens	Q8N122	Anti Tag CoIP	12408816
Intra	MLST8	Q9BVC4	MTOR	Homo sapiens	P42345	Anti Tag CoIP	12408816
Intra	MLST8	Q9BVC4	MTOR	Homo sapiens	P42345	Anti Tag CoIP	20562859
Intra	MLST8	Q9BVC4	MTOR	Homo sapiens	P42345	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Subependymal Glioma	Mixed Subependymoma-Ependymoma Subependymal Astrocytoma Who Grade I Ependymal Tumor Glioma, Subependymal
Kidney Angiomyolipoma	Angiomyolipoma Of Kidney Renal Angiomyolipoma
Dravet Syndrome	Severe Myoclonic Epilepsy Of Infancy Severe Myoclonic Epilepsy In Infancy Smei Epileptic Encephalopathy, Early Infantile, 6 DRVT Developmental And Epileptic Encephalopathy 6a Dee6a Eiee6 Developmental And Epileptic Encephalopathy, 6 Dee6 Developmental And Epileptic Encephalopathy 6 Early Infantile Epileptic Encephalopathy 6 Myoclonic Epilepsy, Severe, Of Infancy Sme Severe Myoclonus Epilepsy Of Infancy Borderline Smei Smeb Smeb-M Smeb-O Smeb-Sw Smei-Borderland Smei-Borderland More Than One Feature Smei-Borderland-Myoclonic Seizures Smei-Borderland-Spike Wave Intractable Childhood Epilepsy With Generalized Tonic-Clonic Seizures ICEGTC Infantile Severe Myoclonic Epilepsy Epilepsy, Intractable Childhood, With Generalized Tonic-Clonic Seizures
Subependymal Giant Cell Astrocytoma	Sega Astrocytoma Subependymal Giant Cell Subependymal Giant-Cell Astrocytoma
Benign Ependymoma	Ependymoma Epithelial Ependymoma Who Grade Ii Ependymal Tumor Myxopapillary Ependymoma
Cowden Syndrome 1	Bannayan-Riley-Ruvalcaba Syndrome Pten Hamartoma Tumor Syndrome Lhermitte-Duclos Disease Bannayan-Zonana Syndrome Phts Riley-Smith Syndrome Bzs Ruvalcaba-Myhre-Smith Syndrome Multiple Hamartoma Syndrome Rmss Brrs Dysplastic Gangliocytoma Of The Cerebellum CWS1 Cs Cd Mham Pten Hamartoma Tumor Syndrome With Granular Cell Tumor Macrocephaly Multiple Lipomas And Hemangiomata Bannayan-Ruvalcaba-Riley Syndrome Myhre-Riley-Smith Syndrome LDD Cerebelloparenchymal Disorder Vi Hamartoma Syndrome, Multiple Bbrs Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata Macrocephaly, Multiple Lipomas, And Hemangiomata Macrocephaly Pseudopapilledema And Multiple Hemangiomas Ruvalcaba -Myhre-Smith Syndrome Ruvalcaba-Myhre Syndrome Cowden Disease Macrocephaly Pseudopapilledema And Multiple Hemangiomata Cerebellar Granule Cell Hypertrophy And Megalencephaly Cpd6 Pten Hamartoma Tumor Syndromes Cowden Syndrome, Type 1
Withdrawal Disorder	Withdrawal Syndrome Substance Withdrawal Syndrome
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 X-Linked Intellectual Disability And Macroorchidism Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Neurodegeneration With Brain Iron Accumulation	Nbia Neurodegeneration With Brain Iron Accumulation Disorders Neurodegeneration, With Brain Iron Accumulation
Cowden Syndrome	Cowden Disease Multiple Hamartoma Syndrome Cowden'S Disease Lhermitte-Duclos Disease Cd Cs Mham Dysplastic Gangliocytoma Of Cerebellum Cowden'S Syndrome Hamartoma Syndrome, Multiple

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08502	MLST8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22642	Mlst8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29157	Mlst8 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MLST8	VGNC	VGNC:74820
Mus musculus	MLST8	MGD	MGI:1929514
Rattus norvegicus	MLST8	RGD	RGD:69242
Felis catus	MLST8	VGNC	VGNC:63527
Bos taurus	MLST8	VGNC	VGNC:31507
Canis familiaris	MLST8	VGNC	VGNC:43266
Others	MLST8	NCBI