3096503-40-8
3096503-40-8
Chemical Structure
HC278
- CAS No.: 3096503-40-8
- Formula:C43H39F3N6O5
- Molecular Weight:776.80
InChIKey: AJQAXIIJKPCAOP-XVNGORCSSA-N
SMILES: O=C1C2=CC=C(N3CCN(CC3)CC4=CC=CC([C@H](C)NC(C5=CC6=C(C(OC7=CC=C(C=C7)C(F)(F)F)=CC=C6)C=C5)=O)=N4)C=C2CN1C8C(NC(CC8)=O)=O
Biological Activity: HC278 is a selective TEAD1/TEAD3 PROTAC degrader. HC278 induces proteasome-dependent degradation by forming a stable ternary complex with CRBN/DDB1. HC278 is applicable to the research of mesothelioma[1].
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HC278 | HC278 is a selective TEAD1/TEAD3 PROTAC degrader. HC278 induces proteasome-dependent degradation by forming a stable ternary complex with CRBN/DDB1. HC278 is applicable to the research of mesothelioma. | |||||||||||||||||||||
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References
Keywords
