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IFIT5 - interferon induced protein with tetratricopeptide repeats 5 Gene

Also Known as P58; RI58; ISG58

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 24138

About IFIT5

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:89,414,568-89,420,997 (from NCBI)

This gene has 8 transcripts (splice variants), 527 orthologues and 4 paralogues. Ubiquitous expression in spleen (RPKM 7.8), lung (RPKM 7.7) and 25 other tissues.

Summary

Enables nucleic acid binding activity. Involved in defense response to virus; negative regulation of viral genome replication; and positive regulation of I-kappaB kinase/NF-kappaB signaling. Located in actin cytoskeleton; apical part of cell; and ruffle membrane. Colocalizes with IkappaB kinase complex. [provided by Alliance of Genome Resources, Apr 2022]

IFIT5 Products (1)

mRNA	Protein	Name
NM_012420.3	NP_036552.1	interferon-induced protein with tetratricopeptide repeats 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA binding	IDA IDA: Inferred from direct assay	21642987	GOA
enables RNA cap binding	IDA IDA: Inferred from direct assay	25092312	GOA
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	23774268	GOA
enables poly(U) RNA binding	IDA IDA: Inferred from direct assay	25092312	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26334375	GOA
enables single-stranded RNA binding	IDA IDA: Inferred from direct assay	23334420	GOA
enables tRNA binding	IDA IDA: Inferred from direct assay	23317505	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	23334420	GOA
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	23774268	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	26334375	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of IkappaB kinase complex	IMP IMP: Inferred from mutant phenotype	26334375	GOA
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	23317505	GOA
located in apical part of cell	IDA IDA: Inferred from direct assay	23317505	GOA
located in ruffle membrane	IDA IDA: Inferred from direct assay	23317505	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFIT5 Protein Structure

TPR_12

TPR_2

TPR_11

TPR_1

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300
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482 a.a.

Protein Preferred Names	Protein Names
interferon-induced protein with tetratricopeptide repeats 5	IFIT-5

Related Diseases

Diseases	Alias
Zika Virus Congenital Syndrome	Zikv Congenital Infection
Avian Influenza	Bird Flu Influenza In Birds Avian Flu

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06564	IFIT5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown