Gabra6 - gamma-aminobutyric acid type A receptor subunit alpha6 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 29708

Summary

Enables diazepam binding activity and inhibitory extracellular ligand-gated ion channel activity. Contributes to GABA-A receptor activity; GABA-gated chloride ion channel activity; and benzodiazepine receptor activity. Involved in GABAergic synaptic transmission. Located in dendrite; neuronal cell body membrane; and synaptic membrane. Is integral component of plasma membrane. Part of receptor complex. Is active in GABA-ergic synapse; cerebellar Golgi cell to granule cell synapse; and hippocampal mossy fiber to CA3 synapse. Is integral component of postsynaptic specialization membrane. Used to study obesity. Orthologous to human GABRA6 (gamma-aminobutyric acid type A receptor subunit alpha6). [provided by Alliance of Genome Resources, Apr 2022]

Gabra6 Products (1)

mRNA	Protein	Name
NM_021841.2	NP_068613.2	gamma-aminobutyric acid receptor subunit alpha-6 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to GABA-A receptor activity	IDA IDA: Inferred from direct assay	17395622	RGD
contributes to GABA-gated chloride ion channel activity	IMP IMP: Inferred from mutant phenotype	17395622	RGD
contributes to benzodiazepine receptor activity	IMP IMP: Inferred from mutant phenotype	16554486	RGD
enables diazepam binding	IDA IDA: Inferred from direct assay	2166916	RGD
enables heterocyclic compound binding	IDA IDA: Inferred from direct assay	2166916	RGD
enables inhibitory extracellular ligand-gated monoatomic ion channel activity	IMP IMP: Inferred from mutant phenotype	16554486	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	14713300	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in response to ethanol	IEP IEP: Inferred from expression pattern	23413777	RGD
involved in synaptic transmission, GABAergic	IMP IMP: Inferred from mutant phenotype	16554486	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	8613776	RGD
is active in cerebellar Golgi cell to granule cell synapse	IDA IDA: Inferred from direct assay	8613776	RGD
located in dendrite	IDA IDA: Inferred from direct assay	8613776	RGD
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	8613776	RGD
located in neuronal cell body membrane	IDA IDA: Inferred from direct assay	8613776	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	9464994	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	8613776	RGD
is active in postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	8613776	RGD
located in postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	9464994	RGD
located in presynaptic membrane	IDA IDA: Inferred from direct assay	17303643	RGD
part of receptor complex	IDA IDA: Inferred from direct assay	14713300	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
gamma-aminobutyric acid receptor subunit alpha-6	GABA(A) receptor subunit alpha-6 GABA-A receptor alpha-6 subunit gamma-aminobutyric acid (GABA) A receptor, alpha 6 gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 6 gamma-aminobutyric acid A receptor, alpha 6 gamma-aminobutyric acid type A

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05214	GABRA6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gabra6	NCBI	NCBI:2559