2688758-23-6
Chemical Structure
PiF
- CAS 番号: 2688758-23-6
- Formula:C26H26F4N2O5S
- Molecular Weight:554.55
InChIKey: JSCRCGCFLXQQFL-UHFFFAOYSA-N
SMILES: COC1=C(C=C(C=C1C)C2=C3C=CC(C=C3OC4=C2C=CC(N(CCF)C)=C4)=N)C.O=S(C(F)(F)F)(O)=O
Biological Activity: PiF is a fluorescent probe with high specificity for pancreatic β-cells (Ex/Em = 535 nm/565 nm), and its fluorescence signal increases significantly with elevated insulin concentrations in in vitro experiments. PiF enables visualization of rat and human islets transplanted via the portal vein in mouse livers with low liver background signals. The fluorine atom of PiF can be replaced by radioactive 18F to prepare a PET tracer. PiF can be used for research on type 1 diabetes[1].
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PiF | PiF is a fluorescent probe with high specificity for pancreatic β-cells (Ex/Em = 535 nm/565 nm), and its fluorescence signal increases significantly with elevated insulin concentrations in in vitro experiments. PiF enables visualization of rat and human islets transplanted via the portal vein in mouse livers with low liver background signals. The fluorine atom of PiF can be replaced by radioactive 18F to prepare a PET tracer. PiF can be used for research on type 1 diabetes. | |||||||||||||||||||||
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Keywords
