3057939-66-6
Chemical Structure
Gly-PEG3-BA
- CAS 番号: 3057939-66-6
- Formula:C34H48ClN8O7P
- Molecular Weight:747.22
InChIKey: ONJAORQDMJYQLO-UHFFFAOYSA-N
SMILES: O=C(CN)NCCOCCOCCOCCC(N1CCN(CC1)C2=CC=C(C(OC)=C2)NC3=NC=C(C(NC4=C(P(C)(C)=O)C=CC=C4)=N3)Cl)=O
Biological Activity: Gly-PEG3-BA is an EML4-ALK PROTAC degrader. Gly-PEG3-BA effectively reduces EML4-ALK with a DC50 value of 0.50 μM in H3122 (EML4-ALK) cells. Gly-PEG3-BA effectively reduces EGFR mutant (L858R/T790M) levels with a DC50 of 20.15 μM in H1975 (EGER-L858R/T790M) cells. Gly-PEG3-BA exerts potent antiproliferation activity in H3122 (EML4-ALK) and H1975 (EGER-L858R/T790M) cells with IC50s value of 0.84 and 20.74 μM. Gly-PEG3-BA can be used for non-small lung cancer research[1].
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Gly-PEG3-BA | Gly-PEG3-BA is an EML4-ALK PROTAC degrader. Gly-PEG3-BA effectively reduces EML4-ALK with a DC50 value of 0.50 μM in H3122 (EML4-ALK) cells. Gly-PEG3-BA effectively reduces EGFR mutant (L858R/T790M) levels with a DC50 of 20.15 μM in H1975 (EGER-L858R/T790M) cells. Gly-PEG3-BA exerts potent antiproliferation activity in H3122 (EML4-ALK) and H1975 (EGER-L858R/T790M) cells with IC50s value of 0.84 and 20.74 μM. Gly-PEG3-BA can be used for non-small lung cancer research. | |||||||||||||||||||||
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Keywords
