3107363-68-5
3107363-68-5
Chemical Structure
TRPM8 antagonist 4
- CAS 番号: 3107363-68-5
- Formula:C20H27NO3
- Molecular Weight:329.43
InChIKey: DWQHNKCFLLLAQZ-NTEUORMPSA-N
SMILES: O=C(N)C1=C(O)C=C(OC/C=C(C)/CC/C=C(C)/C)C=C1C2CC2
Biological Activity: TRPM8 antagonist 4 is a CB2R partial agonist (EC50=54.2 nM, Ki=3.2 μM) and TRPM8 antagonists (IC50=42.3 nM) with high functional selectivity and good physicochemical properties. TRPM8 antagonist 4 has significant anti-inflammatory and analgesic effects and good safety, reduces the mRNA expression of TNF-α, IL-6, and IL-1β[1].
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TRPM8 antagonist 4 | TRPM8 antagonist 4 is a CB2R partial agonist (EC50=54.2 nM, Ki=3.2 μM) and TRPM8 antagonists (IC50=42.3 nM) with high functional selectivity and good physicochemical properties. TRPM8 antagonist 4 has significant anti-inflammatory and analgesic effects and good safety, reduces the mRNA expression of TNF-α, IL-6, and IL-1β. | |||||||||||||||||||||
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References
Keywords
