313527-11-6
Chemical Structure
RK-0080552
Synonym(s): RK-552
- CAS 番号: 313527-11-6
- Formula:C12H6N6O2
- Molecular Weight:266.22
InChIKey: KDJJKMFOUNGOLL-UHFFFAOYSA-N
SMILES: NC1=NON=C1C(N=N2)=NC3=C2C(C4=C3C=CC=C4)=O
Biological Activity: RK-0080552 (RK-552) is a NSD2 inhibitor with an IC50 of 0.11 μM, and it exhibits selectivity over histone methyltransferases G9a (IC50: 1.2 μM) and SET7/9 (IC50: >50 μM). RK-0080552 functionally inhibits NSD2 histone methyltransferase activity, reduces the dimethylation level of histone H3 lysine 36, suppresses IRF4 transcription, induces apoptosis and triggers cell death. RK-0080552 inhibits the growth of xenograft tumors and prolongs host survival. RK-0080552 is available for the research of multiple myeloma[1].
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RK-0080552 | RK-0080552 (RK-552) is a NSD2 inhibitor with an IC50 of 0.11 μM, and it exhibits selectivity over histone methyltransferases G9a (IC50: 1.2 μM) and SET7/9 (IC50: >50 μM). RK-0080552 functionally inhibits NSD2 histone methyltransferase activity, reduces the dimethylation level of histone H3 lysine 36, suppresses IRF4 transcription, induces apoptosis and triggers cell death. RK-0080552 inhibits the growth of xenograft tumors and prolongs host survival. RK-0080552 is available for the research of multiple myeloma. | |||||||||||||||||||||
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Keywords
