871507-11-8
871507-11-8
Chemical Structure
Mardepodect precursor
- CAS 番号: 871507-11-8
- Formula:C24H18N4O
- Molecular Weight:378.43
InChIKey: VRWJZGHUCOFGPZ-UHFFFAOYSA-N
SMILES: C1(C2=CNN=C2C3=CC=C(OCC4=NC5=C(C=C4)C=CC=C5)C=C3)=CC=NC=C1
Biological Activity: Mardepodect precursor is the precursor of Mardepodect (HY-50098). Mardepodect precursor. Mardepodect is a potent, selective orally active, and brain-penetrant PDE10A inhibitor with an IC50 of 0.37 nM, with >1000-fold selectivity over other PDEs[1][2].
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Mardepodect precursor | Mardepodect precursor is the precursor of Mardepodect (HY-50098). Mardepodect precursor. Mardepodect is a potent, selective orally active, and brain-penetrant PDE10A inhibitor with an IC50 of 0.37 nM, with >1000-fold selectivity over other PDEs. | |||||||||||||||||||||
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References
- [1]. Verhoest PR, et al. Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia. J Med Chem, 2009, 52(16), 5188-5196. [Content Brief]
- [2]. Grauer SM, et al. Phosphodiesterase 10A inhibitor activity in preclinical models of the positive, cognitive, and negative symptoms of schizophrenia. J Pharmacol Exp Ther, 2009, 331(2), 574-590. [Content Brief]
Keywords
