FGD2 - FYVE, RhoGEF and PH domain containing 2 Gene

Also Known as ZFYVE4

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 221472

About FGD2

Cytogenetic location: 6p21.2 Genomic coordinates (GRCh38): 6:37,005,655-37,029,069 (from NCBI)

This gene has 11 transcripts (splice variants), 135 orthologues and 10 paralogues. Biased expression in spleen (RPKM 19.9), lymph node (RPKM 9.1) and 13 other tissues.

Summary

The protein encoded by this gene belongs to a family of guanine nucleotide exchange factors (GEFs) which control cytoskeleton-dependent membrane rearrangements by activating the cell division cycle 42 (CDC42) protein. This gene is expressed in B lymphocytes, macrophages, and dendritic cells. The encoded protein may play a role in leukocyte signaling and vesicle trafficking in antigen-presenting cells in the immune system. [provided by RefSeq, Oct 2016]

FGD2 Products (1)

mRNA Protein Name
NM_173558.4 NP_775829.2 FYVE, RhoGEF and PH domain-containing protein 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FGD2 Protein Structure

RhoGEF

RhoGEF: RhoGEF domain (106 - 288)

PH

PH: PH domain (322 - 417)

FYVE

FYVE: FYVE zinc finger (453 - 516)

  • 0
  • 200
  • 400
  • 600
  • 655 a.a.
Protein Preferred Names Protein Names

FYVE, RhoGEF and PH domain-containing protein 2

  • FGD1 family, member 2

FGD2 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
FGD2 Q7Z6J4 RPRM Homo sapiens Q9NS64
Validated Y2H
32296183
Intra
FGD2 Q7Z6J4 RPRM Homo sapiens Q9NS64
Y2H Array
32296183
Intra
FGD2 Q7Z6J4 RPRM Homo sapiens Q9NS64
Y2H Prey Pooling
32296183
Intra
FGD2 Q7Z6J4 KLHL12 Homo sapiens Q53G59
Y2H Array
25416956
Intra
FGD2 Q7Z6J4 KLHL12 Homo sapiens Q53G59
Y2H Prey Pooling
25416956
Intra
FGD2 Q7Z6J4 KLHL12 Homo sapiens Q53G59
Validated Y2H
25416956
Intra
FGD2 Q7Z6J4 PLEKHG4 Homo sapiens Q58EX7
Y2H Prey Pooling
32296183
Intra
FGD2 Q7Z6J4 PLEKHG4 Homo sapiens Q58EX7
Y2H Array
32296183
Intra
FGD2 Q7Z6J4 TMEM239 Homo sapiens Q8WW34
Y2H Prey Pooling
25416956
Intra
FGD2 Q7Z6J4 TMEM239 Homo sapiens Q8WW34
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS04881 FGD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08638 MRAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus FGD2 MGD MGI:1347084
Bos taurus FGD2 VGNC VGNC:28965
Macaca mulatta FGD2 VGNC VGNC:72643
Felis catus FGD2 VGNC VGNC:62240
Canis familiaris FGD2 VGNC VGNC:40834
Rattus norvegicus FGD2 RGD RGD:1309840
Others FGD2 NCBI