Prickle2 - prickle planar cell polarity protein 2 Gene

Also Known as Pk2; mpk2; 6230400G14Rik; 6720451F06Rik

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 243548

Summary

Predicted to enable zinc ion binding activity. Acts upstream of or within several processes, including establishment or maintenance of epithelial cell apical/basal polarity; neuron projection development; and trophectodermal cell fate commitment. Located in several cellular components, including apicolateral plasma membrane; lateral plasma membrane; and nucleus. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; notochord; and primitive streak. Orthologous to human PRICKLE2 (prickle planar cell polarity protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Prickle2 Products (5)

mRNA Protein Name
NM_001081146.3 NP_001074615.1 prickle-like protein 2 isoform a
NM_001134459.2 NP_001127931.1 prickle-like protein 2 isoform b
NM_001134460.3 NP_001127932.1 prickle-like protein 2 isoform b
NM_001134461.2 NP_001127933.1 prickle-like protein 2 isoform b
NM_001404086.1 NP_001391015.1 prickle-like protein 2 isoform c

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
19788910 MGI
Biological Process GO Annotation Evidence 参考文献 由来
involved in embryonic brain development IMP
IMP: Inferred from mutant phenotype
17868671 MGI
acts upstream of or within establishment or maintenance of epithelial cell apical/basal polarity IDA
IDA: Inferred from direct assay
17376975 MGI
involved in maintenance of postsynaptic density structure IDA
IDA: Inferred from direct assay
34613779 MGI
involved in maintenance of postsynaptic density structure IMP
IMP: Inferred from mutant phenotype
34613779 MGI
acts upstream of or within neuron projection development IMP
IMP: Inferred from mutant phenotype
19788910 MGI
involved in neuron projection development IMP
IMP: Inferred from mutant phenotype
17868671 MGI
involved in regulation of postsynaptic density assembly IDA
IDA: Inferred from direct assay
23711981 MGI
involved in regulation of postsynaptic density assembly IMP
IMP: Inferred from mutant phenotype
23711981 MGI
involved in response to electrical stimulus IMP
IMP: Inferred from mutant phenotype
21276947 MGI
Cellular Component GO Annotation Evidence 参考文献 由来
located in apicolateral plasma membrane IDA
IDA: Inferred from direct assay
17376975 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
22333836 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
23711981 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
23711981 MGI
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
17376975 MGI
is active in postsynaptic density IDA
IDA: Inferred from direct assay
21324980 MGI
is active in postsynaptic density IEP
IEP: Inferred from expression pattern
21324980 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prickle-like protein 2

  • prickle homolog 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS11094 PRICKLE2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Prickle2 NCBI NCBI:166336