TTLL3 - tubulin tyrosine ligase like 3 Gene
Also Known as HOTTL
Species: Homo sapiens
About TTLL3
This gene has 35 transcripts (splice variants), 240 orthologues and 12 paralogues. Ubiquitous expression in ovary (RPKM 13.9), testis (RPKM 13.9) and 24 other tissues.
Summary
Enables protein-glycine Ligase activity. Predicted to be involved in axoneme assembly and flagellated sperm motility. Predicted to be located in axoneme; microtubule cytoskeleton; and sperm flagellum. [provided by Alliance of Genome Resources, Apr 2022]
TTLL3 Products (24)
| mRNA | Protein | Name |
|---|---|---|
| NM_001025930.5 | NP_001021100.3 | tubulin monoglycylase TTLL3 isoform 1 |
| NM_001366051.2 | NP_001352980.1 | tubulin monoglycylase TTLL3 isoform 2 |
| NM_001387446.1 | NP_001374375.1 | tubulin monoglycylase TTLL3 isoform 3 |
| NM_001387447.1 | NP_001374376.1 | tubulin monoglycylase TTLL3 isoform 4 |
| NM_001387448.1 | NP_001374377.1 | tubulin monoglycylase TTLL3 isoform 5 |
| NM_001387449.1 | NP_001374378.1 | tubulin monoglycylase TTLL3 isoform 6 |
| NM_001387450.1 | NP_001374379.1 | tubulin monoglycylase TTLL3 isoform 7 |
| NM_001387451.1 | NP_001374380.1 | tubulin monoglycylase TTLL3 isoform 8 |
| NM_001387452.1 | NP_001374381.1 | tubulin monoglycylase TTLL3 isoform 9 |
| NM_001387453.1 | NP_001374382.1 | tubulin monoglycylase TTLL3 isoform 10 |
| NM_001387454.1 | NP_001374383.1 | tubulin monoglycylase TTLL3 isoform 11 |
| NM_001387455.1 | NP_001374384.1 | tubulin monoglycylase TTLL3 isoform 11 |
| NM_001387456.1 | NP_001374385.1 | tubulin monoglycylase TTLL3 isoform 11 |
| NM_001387457.1 | NP_001374386.1 | tubulin monoglycylase TTLL3 isoform 12 |
| NM_001387458.1 | NP_001374387.1 | tubulin monoglycylase TTLL3 isoform 13 |
| NM_001387459.1 | NP_001374388.1 | tubulin monoglycylase TTLL3 isoform 14 |
| NM_001387460.1 | NP_001374389.1 | tubulin monoglycylase TTLL3 isoform 14 |
| NM_001387461.1 | NP_001374390.1 | tubulin monoglycylase TTLL3 isoform 15 |
| NM_001387462.1 | NP_001374391.1 | tubulin monoglycylase TTLL3 isoform 16 |
| NM_001387463.1 | NP_001374392.1 | tubulin monoglycylase TTLL3 isoform 17 |
| NM_001387464.1 | NP_001374393.1 | tubulin monoglycylase TTLL3 isoform 18 |
| NM_001387465.1 | NP_001374394.1 | tubulin monoglycylase TTLL3 isoform 18 |
| NM_001387466.1 | NP_001374395.1 | tubulin monoglycylase TTLL3 isoform 19 |
| NM_001387467.1 | NP_001374396.1 | tubulin monoglycylase TTLL3 isoform 20 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein-glycine ligase activity |
IDA
IDA: Inferred from direct assay
|
19524510 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| NOT involved in protein polyglycylation |
IDA
IDA: Inferred from direct assay
|
19524510 | GOA |
TTLL3 Protein Structure
TTL: Tubulin-tyrosine ligase family (359 - 644)
- 0
- 200
- 400
- 600
- 800
- 915 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
tubulin monoglycylase TTLL3 |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Noonan Syndrome 1 |
|
|
| Fanconi Anemia, Complementation Group A |
|
|
| Primary Ciliary Dyskinesia |
|
|