Sorbs3 - sorbin and SH3 domain containing 3 Gene

Predicted to enable vinculin binding activity. Predicted to be involved in cell-substrate adhesion and positive regulation of stress fiber assembly. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II and positive regulation of MAPK cascade. Predicted to be active in cell-substrate junction; cytoplasm; and nucleus. Predicted to colocalize with focal adhesion. Orthologous to human SORBS3 (sorbin and SH3 domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]