KCNRG - potassium channel regulator Gene

Also Known as DLTET

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 283518

About KCNRG

Cytogenetic location: 13q14.2 Genomic coordinates (GRCh38): 13:50,015,444-50,020,922 (from NCBI)

This gene has 2 transcripts (splice variants), 130 orthologues and 13 paralogues. Broad expression in testis (RPKM 38.4), bone marrow (RPKM 16.2) and 24 other tissues.

Summary

This gene encodes a protein which regulates the activity of voltage-gated potassium channels. This gene is on chromosome 13 and overlaps the gene for tripartite motif containing 13 on the same strand. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

KCNRG Products (2)

mRNA	Protein	Name
NM_173605.2	NP_775876.1	potassium channel regulatory protein isoform 1
NM_199464.3	NP_955751.1	potassium channel regulatory protein isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19968958	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in negative regulation of delayed rectifier potassium channel activity	IDA IDA: Inferred from direct assay	19968958	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	19968958	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNRG Protein Structure

BTB_2

0
100
200
272 a.a.

Protein Preferred Names	Protein Names
potassium channel regulatory protein	putative potassium channel regulatory protein

KCNRG Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	KCNRG	Q8N5I3	FOSL1	Homo sapiens	P15407	Anti Tag CoIP	33961781
Intra	KCNRG	Q8N5I3	KCNRG	Homo sapiens	Q8N5I3	Y2H Pooling	16189514
Intra	KCNRG	Q8N5I3	KCNRG	Homo sapiens	Q8N5I3	Y2H Pooling	19447967
Intra	KCNRG	Q8N5I3	KCNRG	Homo sapiens	Q8N5I3	Validated Y2H	32296183
Intra	KCNRG	Q8N5I3	metE	Bacillus anthracis	Q6KNA9	Y2H Pooling	20711500
Intra	KCNRG	Q8N5I3	ROBO2	Homo sapiens	Q9HCK4	Y2H	21900206
Intra	KCNRG	Q8N5I3	ARHGDIA	Homo sapiens	P52565	Y2H	21900206
Intra	KCNRG	Q8N5I3	KCNRG	Homo sapiens	Q8N5I3	Pull Down	16189514
Intra	KCNRG	Q8N5I3	KCNRG	Homo sapiens	Q8N5I3	Y2H Prey Pooling	32296183
Intra	KCNRG	Q8N5I3	KCNRG	Homo sapiens	Q8N5I3	Y2H Array	25416956
Intra	KCNRG	Q8N5I3	KCNRG	Homo sapiens	Q8N5I3	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Autoimmune Polyendocrine Syndrome Type 1	Whitaker Syndrome Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Autoimmune Polyglandular Syndrome I Polyglandular Type I Autoimmune Syndrome
Autoimmune Polyendocrine Syndrome	Autoimmune Polyendocrinopathy Autoimmune Polyglandular Failure Autoimmune Polyglandular Syndrome Polyendocrinopathies, Autoimmune Lloyd'S Syndrome Aps Polyendocrinopathies Autoimmune Polyendocrine Autoimmunity Syndrome Lloyd Syndrome Polyglandular Autoimmune Deficiency Progressive Pluriglandular Insufficiency Pluriglandular Autoimmune Atrophy Pluriglandular Autoimmune Syndrome Thyroid-Adrenocortical Insufficiency Syndrome
Chronic Mucocutaneous Candidiasis	Candidiasis, Chronic Mucocutaneous Cmc Candidiasis Chronic Mucocutaneous
Nail Disease	Nail Diseases Abnormality Of The Nail Nail Anomaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS07178	KCNRG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Macaca mulatta	KCNRG	VGNC	VGNC:73859
Rattus norvegicus	KCNRG	RGD	RGD:1307199
Canis familiaris	KCNRG	VGNC	VGNC:42292
Mus musculus	KCNRG	MGD	MGI:2685591
Felis catus	KCNRG	VGNC	VGNC:63046
Bos taurus	KCNRG	VGNC	VGNC:30490
Others	KCNRG	NCBI