HSD3B2 - Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 Gene

Also Known as Hsd3b1; Hsd3b6; Hsd3b2l1

生物種: Rattus norvegicus

遺伝子タイプ: protein coding
遺伝子ID: 29632

Summary

Enables 3-beta-hydroxy-delta5-steroid dehydrogenase activity and steroid delta-isomerase activity. Involved in several processes, including Leydig cell differentiation; response to corticosterone; and steroid hormone biosynthetic process. Predicted to be located in endoplasmic reticulum; intercellular bridge; and nucleolus. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Biomarker of hyperprolactinemia and hypertension. Human ortholog(s) of this gene implicated in hypospadias. Orthologous to human HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2). [provided by Alliance of Genome Resources, Apr 2022]

HSD3B2 Products (1)

mRNA Protein Name
NM_017265.4 NP_058961.4 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
1985917 RGD
enables steroid delta-isomerase activity IDA
IDA: Inferred from direct assay
1985917 RGD
Biological Process GO Annotation Evidence 参考文献 由来
involved in C21-steroid hormone biosynthetic process IDA
IDA: Inferred from direct assay
1985917 RGD
involved in Leydig cell differentiation IEP
IEP: Inferred from expression pattern
18502897 RGD
involved in androgen biosynthetic process IDA
IDA: Inferred from direct assay
1985917 RGD
involved in hippocampus development IEP
IEP: Inferred from expression pattern
21047951 RGD
involved in negative regulation of iron ion transport IMP
IMP: Inferred from mutant phenotype
16116051 RGD
involved in response to cadmium ion IEP
IEP: Inferred from expression pattern
18972398 RGD
involved in response to corticosterone IEP
IEP: Inferred from expression pattern
8027581 RGD
involved in response to gonadotropin IEP
IEP: Inferred from expression pattern
16139340 RGD
involved in response to lead ion IEP
IEP: Inferred from expression pattern
18972398 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4

  • 3 beta-hydroxysteroid dehydrogenase 6

  • 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type IV

  • 3-beta-HSD IV

  • Hydroxy-delta-5-steroid dehydrogenase 3 beta- and steroid delta-isomerase

  • hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS06402 HSD3B2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens HSD3B2 NCBI NCBI:3284