VPREB3 - V-set pre-B cell surrogate light chain 3 Gene

Also Known as 8HS20; N27C7-2

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 29802

About VPREB3

Cytogenetic location: 22q11.23 Genomic coordinates (GRCh38): 22:23,752,743-23,754,425 (from NCBI)

This gene has 2 transcripts (splice variants), 111 orthologues and 93 paralogues. Biased expression in lymph node (RPKM 35.6), spleen (RPKM 23.3) and 5 other tissues.

Summary

The protein encoded by this gene is the human ortholog of the mouse VpreB3 (8HS20) protein, is thought to be involved in B-cell maturation, and may play a role in assembly of the pre-B cell receptor (pre-BCR). While the role of this protein in B-cell development has not yet been elucidated, studies with the chicken ortholog of this protein have found that when overexpressed, this protein localizes to the endoplasmic reticulum. The mouse ortholog of this protein has been shown to associate with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. Expression of this gene has been observed in some lymphomas. [provided by RefSeq, Apr 2015]

VPREB3 Products (1)

mRNA	Protein	Name
NM_013378.3	NP_037510.1	pre-B lymphocyte protein 3 precursor

VPREB3 Protein Structure

V-set

0
100
123 a.a.

Protein Preferred Names	Protein Names
pre-B lymphocyte protein 3	pre-B lymphocyte 3

関連疾患

Diseases	Alias
Spondylometaphyseal Dysplasia, Sedaghatian Type	SMDS Sedaghatian Chondrodysplasia Spondylometaphyseal Dysplasia Sedaghatian Type Congenital Lethal Metaphyseal Chondrodysplasia Metaphyseal Chondrodysplasia, Congenital Lethal Lethal Metaphyseal Dysplasia
Agammaglobulinemia 4, Autosomal Recessive	Agammaglobulinemia 4 AGM4 Agammaglobulinemia, Autosomal Recessive, Due To Blnk Defect B Cell Linker Protein Deficiency B-Cell Linker Protein Deficiency Blnk Deficiency Agammaglobulinemia Autosomal Recessive Due To Blnk Defect Agammaglobulinemia, Type 4, Autosomal Recessive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS15670	VPREB3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	VPREB3	RGD	RGD:1306807
Bos taurus	VPREB3	VGNC	VGNC:53929
Felis catus	VPREB3	VGNC	VGNC:66952
Canis familiaris	VPREB3	VGNC	VGNC:48272
Macaca mulatta	VPREB3	VGNC	VGNC:108070
Mus musculus	VPREB3	MGD	MGI:98938