SLC25A24 - solute carrier family 25 member 24 Gene

Also Known as APC1; SCAMC1; SCAMC-1

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 29957

About SLC25A24

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:108,134,043-108,200,343 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 189 orthologues, 49 paralogues and is associated with 4 phenotypes. Ubiquitous expression in small intestine (RPKM 21.4), colon (RPKM 20.9) and 25 other tissues.

Summary

This gene encodes a carrier protein that transports ATP-Mg exchanging it for phosphate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

SLC25A24 Products (4)

mRNA	Protein	Name
NM_013386.5	NP_037518.3	calcium-binding mitochondrial carrier protein SCaMC-1 isoform 1
NM_213651.3	NP_998816.1	calcium-binding mitochondrial carrier protein SCaMC-1 isoform 2
NM_013386.5	NP_037518.3	calcium-binding mitochondrial carrier protein SCaMC-1 isoform 1
NM_213651.3	NP_998816.1	calcium-binding mitochondrial carrier protein SCaMC-1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables ADP:phosphate antiporter activity	IDA IDA: Inferred from direct assay	15123600	GOA
enables ATP transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	22015608	GOA
enables ATP:phosphate antiporter activity	IDA IDA: Inferred from direct assay	15123600	GOA
enables adenine nucleotide transmembrane transporter activity	IDA IDA: Inferred from direct assay	15123600	GOA
enables calcium ion binding	EXP EXP: Inferred from Experiment	24332718	GOA
enables calcium ion binding	IDA IDA: Inferred from direct assay	24332718	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in adenine nucleotide transport	IDA IDA: Inferred from direct assay	15123600	GOA
involved in cellular response to calcium ion	IMP IMP: Inferred from mutant phenotype	22015608	GOA
involved in cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	29100093	GOA
involved in mitochondrial ATP transmembrane transport	IDA IDA: Inferred from direct assay	15123600	GOA
involved in mitochondrial ATP transmembrane transport	IMP IMP: Inferred from mutant phenotype	22015608	GOA
involved in mitochondrial transport	IMP IMP: Inferred from mutant phenotype	29100093	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in membrane	IDA IDA: Inferred from direct assay	24332718	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	15054102	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC25A24 Protein Structure

EF-hand_7

Mito_carr

0
100
200
300
400
477 a.a.

Protein Preferred Names	Protein Names
calcium-binding mitochondrial carrier protein SCaMC-1	ATP-Mg/P(i) co-transporter 1

関連疾患

Diseases	Alias
Fontaine Progeroid Syndrome	Gorlin-Chaudhry-Moss Syndrome Gcms Craniofacial Dysostosis, Hypertrichosis, Hypoplasia Of Labia Majora, Dental And Eye Anomalies, Patent Ductus Arteriosus, And Normal Intelligence Gorlin Chaudhry Moss Syndrome Gcm Syndrome FPS Progeroid Syndrome, Congenital, Petty Type Progeroid Syndrome Petty Type Craniofacial Dysostosis, Patent Ductus Arteriosus, Hypertrichosis, Hypoplasia Of Labia Majora, Dental And Eye Anomalies Petty Laxova Wiedemann Syndrome Progeroid Syndrome Congenital Petty Type Craniofacial Dysostosis-Genital, Dental, Cardiac Anomalies Syndrome Cranofacial Dysostosis-Hypertrichosis-Hypoplasia Of Labia Majora Syndrome Dental And Eye Anomalies-Patent Ductus Arteriosus-Normal Intelligence Syndrome Progeroid Syndrome, Petty Type Petty Syndrome Petty-Laxova-Wiedemann Syndrome
Progeroid Syndrome
Dementia	Dementias Presenile Dementia Alzheimer Type Dementia Alzheimer Sclerosis Alzheimer Disease Dementia Alzheimer Dementia Primary Degenerative Alzheimer Type Dementia End Stage Alzheimer'S Dementia Alzheimer'S Type Atypical Dementia Alzheimer Type Presenile Dementia Early Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 2 Dementia In Alzheimer Disease With Early Onset Early Onset Alzheimer Type Dementia, Uncomplicated Primary Degenerative Alzheimer Type Dementia, Early Onset Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated Alzheimer Disease Dementia With Early Onset Presenile Sclerosis Presenile Brain Sclerosis Presenile Alzheimer Brain Sclerosis Late Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 1 Dementia In Alzheimer Disease With Late Onset Primary Degenerative Alzheimer Type Dementia, Late Onset Sdat - [Senile Dementia, Alzheimer Type] Alzheimer Disease Dementia With Late Onset Late Onset Alzheimer Brain Sclerosis Senile Alzheimer Brain Disease Senile Alzheimer Brain Sclerosis Senile Primary Degenerative Alzheimer Type Dementia Senile Dementia Of The Alzheimer Type Arteriosclerotic Dementia Strategic-Infarct Dementia Post Stroke Dementia Vascular Cognitive Impairment Vascular Dementia Dementia Of The Lewy Body Type Dementia With Lewy Bodies Sdlt - [Senile Dementia Of The Lewy Body Type] Senile Dementia Of The Lewy Body Type Alcohol-Related Dementia Alcoholic Dementia Nos Alcohol-Induced Dementia Alcoholic Brain Syndrome Chronic Alcoholic Brain Syndrome Alcohol Dementia Late Onset Alcoholic Psychosis Residual And Late-Onset Alcohol-Induced Psychotic Disorder Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder Late-Onset Psychoactive Substance-Induced Psychotic Disorder Inhalant Dementia Volatile Solvents Dementia Dementia In Paralysis Agitans Pdd - [Parkinson Disease Dementia] Dementia Syndrome Of Parkinson Disease Dementia In Parkinson Disease Parkinson Related Dementia Dementia In Huntington Chorea Hiv - [Human Immunodeficiency Virus] Dementia Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex Aids Related Dementia Dementia Due To Niacin Deficiency
Craniosynostosis	Premature Closure Of Cranial Sutures Craniostenosis Craniosynostosis Syndrome Cso Craniosynostoses Congenital Ossification Of Cranial Sutures Congenital Ossification Of Sutures Of Skull Craniostosis Imperfect Fusion Of Skull Congenital Imperfect Closure Skull Imperfect Closure Skull Premature Closure Cranium Sutures Deficiency Of Craniofacial Axis
Hypertrichosis
Conduct Disorder
Cecum Adenocarcinoma	Cecal Adenocarcinoma Adenocarcinoma Of Cecum
Colon Mucinous Adenocarcinoma	Colonic Mucinous Adenocarcinoma Mucinous Adenocarcinoma Of The Colon
Body Dysmorphic Disorder	Dysmorphophobia Body Dysmorphia Dysmorphic Syndrome Body Dysmorphic Disorders
Umbilical Hernia	Hernia, Umbilical
Sengers Syndrome	Mitochondrial Dna Depletion Syndrome 10 Cardiomyopathy And Cataract Cataract And Cardiomyopathy MTDPS10 Congenital Cataract-Hypertrophic Cardiomyopathy-Mitochondrial Myopathy Syndrome Cardiomyopathic Mitochondrial Dna Depletion Syndrome 10 Senger Syndrome
Myoclonic Epilepsy Associated With Ragged-Red Fibers	Merrf Syndrome MERRF Fukuhara Syndrome Myoclonic Epilepsy Associated With Ragged Red Fibers Myoencephalopathy Ragged-Red Fiber Disease Myoclonic Epilepsy - Ragged Red Fibers Myoclonus Epilepsy And Ragged Red Fibers Myoclonus With Epilepsy And With Ragged Red Fibers Myoclonic Epilepsy With Ragged Red Fibers Myoclonic Epilepsy With Ragged-Red Fibers Fukuhara Disease Myoclonus Epilepsy Associated With Ragged-Red Fibres Myoclonus With Epilepsy With Ragged Red Fibers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS20673	Slc25a24 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13105	SLC25A24 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27184	Slc25a24 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Canis familiaris	SLC25A24	VGNC	VGNC:54068
Mus musculus	SLC25A24	MGD	MGI:1917160
Macaca mulatta	SLC25A24	VGNC	VGNC:100140
Felis catus	SLC25A24	VGNC	VGNC:65265
Bos taurus	SLC25A24	VGNC	VGNC:55682
Rattus norvegicus	SLC25A24	RGD	RGD:1311982