Ocrl - OCRL, inositol polyphosphate-5-phosphatase Gene

Also Known as OCRL1; 9530014D17Rik

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 320634

Summary

Enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Acts upstream of or within in utero embryonic development and phosphatidylinositol dephosphorylation. Predicted to be located in several cellular components, including cytoplasmic vesicle; photoreceptor outer segment; and trans-Golgi network. Predicted to be active in cytoplasm and membrane. Is expressed in several structures, including brain; eye; genitourinary system; heart; and liver. Used to study oculocerebrorenal syndrome. Human ortholog(s) of this gene implicated in Dent disease and oculocerebrorenal syndrome. Orthologous to human OCRL (OCRL inositol polyphosphate-5-phosphatase). [provided by Alliance of Genome Resources, Apr 2022]

Ocrl Products (1)

mRNA Protein Name
NM_177215.3 NP_796189.2 inositol polyphosphate 5-phosphatase OCRL

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IDA
IDA: Inferred from direct assay
9593760 MGI
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of or within in utero embryonic development IGI
IGI: Inferred from genetic interaction
20195868 MGI
acts upstream of or within phosphatidylinositol dephosphorylation IDA
IDA: Inferred from direct assay
9593760 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inositol polyphosphate 5-phosphatase OCRL

  • inositol polyphosphate 5-phosphatase OCRL-1

  • oculocerebrorenal syndrome of Lowe

  • phosphatidylinositol 3,4,5-triphosphate 5-phosphatase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-120354 YU142670 Inhibitor 99.50% Unkown
HY-117087 K103 Inducer / Unkown
HY-RS09746 OCRL Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Ocrl NCBI NCBI:4952